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posted by hubie on Thursday June 30 2022, @02:36AM   Printer-friendly
from the working-on-the-details dept.

https://arstechnica.com/science/2022/06/pig-heart-transplant-failed-as-its-heart-muscle-cells-died/

Earlier this year, news broke of the first experimental xenotransplantation: A human patient with heart disease received a heart from a pig that had been genetically engineered to avoid rejection. While initially successful, the experiment ended two months later when the transplant failed, leading to the death of the patient. At the time, the team didn't disclose any details regarding what went wrong. But this week saw the publication of a research paper that goes through everything that happened to prepare for the transplant and the weeks following.

Critically, this includes the eventual failure of the transplant, which was triggered by the death of many of the muscle cells in the transplanted heart. But the reason for that death isn't clear, and the typical signs of rejection by the immune system weren't present. So, we're going to have to wait a while to understand what went wrong.

[...] The presence of an apparent pig cytomegalovirus was worrying, but the researchers indicate there's some question about whether the tests that picked it up might have been recognizing a closely related human virus—one that's often associated with organ transplant problems.

So, for now, it's not clear what happened with this transplant or what the significance of the apparent viral infection is. Obviously, the team has lots of material to work with to try to figure out what went on, and there's a long, long list of potential experiments to do with it. And there are also additional xenotransplant trials in the works, so it may not be long before we have a better sense of whether this was something specific to this transplant or a general risk of xenotransplantation.

Previously:
Man Who Received a Heart Transplant From a Pig Has Died


Original Submission

Related Stories

Man Who Received a Heart Transplant From a Pig Has Died 16 comments

A man who got the 1st pig heart transplant has died after 2 months

The first person to receive a heart transplant from a pig has died, two months after the groundbreaking experiment, the Maryland hospital that performed the surgery announced Wednesday.

David Bennett, 57, died Tuesday at the University of Maryland Medical Center. Doctors didn't give an exact cause of death, saying only that his condition had begun deteriorating several days earlier.

[...] Prior attempts at such transplants — or xenotransplantation — have failed largely because patients' bodies rapidly rejected the animal organ. This time, the Maryland surgeons used a heart from a gene-edited pig: Scientists had modified the animal to remove pig genes that trigger the hyper-fast rejection and add human genes to help the body accept the organ.

At first the pig heart was functioning, and the Maryland hospital issued periodic updates that Bennett seemed to be slowly recovering. Last month, the hospital released video of him watching the Super Bowl from his hospital bed while working with his physical therapist.

Bennett survived significantly longer with the gene-edited pig heart than one of the last milestones in xenotransplantation — when Baby Fae, a dying California infant, lived 21 days with a baboon's heart in 1984.

[...] One next question is whether scientists have learned enough from Bennett's experience and some other recent experiments with gene-edited pig organs to persuade the FDA to allow a clinical trial — possibly with an organ such as a kidney that isn't immediately fatal if it fails.

Previously: Surgeons Smash Records With Pig-to-Primate Organ Transplants
Surgeons Successfully Transplant Genetically Modified Pig Heart Into Human Patient


Original Submission

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  • (Score: -1, Spam) by Anonymous Coward on Thursday June 30 2022, @03:35AM

    by Anonymous Coward on Thursday June 30 2022, @03:35AM (#1257080)

    Your signature's YOUR UNDOING:

    "Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss hosts files"

    You must be a NO-MIND: Especially as I SHOT YOU DOWN discussing hosts making YOU the SMALLEST NO MIND since I easily tore you apart with FACTS (i.e./e.g. - Paralyzing botnets is EASY if you have the C2 & other servers it uses information - FACT & why security articles post Indicators of Compromise (IOC)).

    ---

    Dalek EXTERMINATED by APK (again)!

    No small wonder he got rid of his OLD SIGNATURE of "exterminate", lol - especially after ALL of the below FACTS:

    FACT: Hosts work vs. Symbiote C2 server(s) per this line from a MUCH better article than the one used here from bradley13 per "configuration in the binary that used the git[.]bancodobrasil[.]dev domain as its C2 server" from https://www.intezer.com/blog/research/new-linux-threat-symbiote/ [intezer.com]

    & did I block that in my original posts here https://soylentnews.org/comments.pl?noupdate=1&sid=49835&page=1&cid=1253504#commentwrap [soylentnews.org] on this BOGUS sockpuppet upmodding yourselves shithole website (which also noted FIREWALLS are invaluable here too, per wildcards (or even IP address use, URL domain/subdomain too in many as well))?

    YES I DID! I was correct!

    FACT: hosts files block symbiote C2 servers which is all you really need to do to nullify their communication.

    FACT: Exfiltration isn't possible without orders either.

    FACT: Orders come from C2 servers!

    When I show people articles that debunk misinformation about COVID-19, the response is often that the articles are from the mainstream media and can't be trusted. It's the same principle, where the information is rejected on the basis of its source, without regard for content. - by dalek (15489) on Wednesday November 17, @06:14PM (#1197102)

    And what did you say to ME hypocrite?

    I'll believe a very prestigious scientific journal like Nature over the sketchy website you keep citing. - by dalek (15489) on Wednesday November 17, @11:30PM (#1197219)

    I showed real results doctors had on video stating it themselves.

    YET All you do is cite MSM VERY FAKE NEWS!

    Proven TONS of times to be so in fact along with their "fact checkers" !

    You're a mindless automaton, incapable of thinking for yourself. If you were capable of critical thinking and logical reasoning, you'd have already been aware that what you're posting is nonsense - by dalek (15489) on Friday November 05, @12:17AM (#1193524)

    I put up what PHD and MDs by the truckload literally let us see (not just YOUR MSM "russia, Russia, RUSSIA" disproven in COURTS vs. Trump very fake news)?

    Do as I say not as I do right dalek?

    You are a hypocrite BS artist that CONTRADICTS himself!

    More from your losing attempt @ DEBATING me (you = IGNORANT FOOL in this area of genetics & TOTALLY undereducated in it - whereas by COMPARISON I am not):

    Your rants about genetics are irrelevant - by dalek (15489) on Friday November 05, @02:17AM (#1193555)

    THIS IS ALL ABOUT GENETICS!

    WHAT IS mRNA after all?

    ANSWER = A part of protein synthesis involving mRNA, tRNA, & rRNA for the creation of DNA!

    IF RNA single helix strands JOIN improperly into a NEW double-helix DNA (via Guanine, Adenine, Cytosine & Thymine) it creates ERRORS (cancer is 1 possible bad one, mutations another etc.)

    See NHEJ below.

    dalek - have you taken any genetics coursework?

    I have & got A's (as my science elective requirement during my CS degreework)!

    vaccines don't contain graphene oxide.- by dalek (15489) on Tuesday October 26, @07:37AM (#1190563)

    1st of all, TONS of vaccines have used poisonous Graphene oxide (or dioxide) as ADJUVANTS over time.

    Secondly: ELECTRON MICROSCOPY EXPERT Dr. Young SHOWS POISONOUS GRAPHENE IN VACCINES ALSO:

    https://www.brighteon.com/9e58bf44-05e7-4b71-97e5-b243f6cf890c [brighteon.com]

    &

    https://www.brighteon.com/9fbd7735-b49d-4e31-a146-f67d7eb54d75 [brighteon.com]

    GRAPHENE OXIDE's in Pfizer, Moderna, Johnson & Johnson (Janssen) + AstraZeneca:

    https://www.brighteon.com/6d8fcfd7-4811-4e64-90c9-bd5585b59ff5 [brighteon.com]

    &

    A major cause of myocarditis, clotting, CANCER MALIGNANCY etc.? That's right: GRAPHENE OXIDE.

    COVID-19 vaccines do not cause cancer - by dalek (15489) on Tuesday October 26, @04:45AM (#1190535)

    Graphene Oxide Promotes Cancer Metastasis https://pubmed.ncbi.nlm.nih.gov/31877027/ [nih.gov]

    An Israeli study PROVES that the NHEJ (non-homologous end joining) mechanism in your cells is DAMAGED by SPIKE PROTEINS in the death vax & IT IS LINKED TO CANCER per https://naturalnews.com/2021-11-02-covid-vaccines-inhibit-dna-repair-cause-cancer.html [naturalnews.com]

    All FROM my +5 upmodded post on COVID killshots (which they HAVE proven to be on TONS of levels) https://soylentnews.org/comments.pl?noupdate=1&sid=46034&page=1&cid=1197563#commentwrap [soylentnews.org]

    you'll attack someone for extended periods of time whenever they show that you're wrong about something, which happens very frequently - by dalek (15489) on Wednesday October 06, @11:10PM (#1184989)

    LOL: Well, there's the BS you state WHERE YOU ATTACKED ME only to DESTROY YOURSELF for me - thank you, lol!

    HOW IRONIC!

    (Dalek "EXTERMINATED" not only by FACTS from experts in microscopy, but DALEK'S own WORDS he has to EAT, lol!)

    NOW THE "ICING ON THE CAKE" EXPOSING YOU, sockpuppeteer UPMODDING YOURSELF obviously + downmod bombing scumbag - RIGHT FROM YOU once more:

    Once this account is old enough to be eligible to moderate, I'll be happy to give you the spam mods you deserve - by dalek (15489) on Wednesday October 06, @11:10PM (#1184989)

    * THANKS FOR SHOWING US YOUR "MODUS OPERANDI" SOCKPUPPETEER troll! Fakename & all for a FAKE like you!

    APK

    P.S.=> THIS? This was just "too, Too, TOO EASY - just '2ez'" & it always IS vs. hypocrites like you, fakename... apk

  • (Score: -1, Spam) by Anonymous Coward on Thursday June 30 2022, @04:32AM

    by Anonymous Coward on Thursday June 30 2022, @04:32AM (#1257089)

    Your signature's YOUR UNDOING! Dalek EXTERMINATED by APK (again)! No small wonder he got rid of his OLD SIGNATURE of "exterminate", lol - especially after ALL of the below FACTS:

    "Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss hosts files"

    Then obviously You're an ALL-TALK mere CHATTERING do-NOTHING & no viable solution offering NO-MIND since I SHOT YOU DOWN discussing hosts as I easily tore you apart w/ FACTS (i.e./e.g. - Paralyzing botnets is EASY if you have the C2 & other servers it uses information - FACT & why security articles post Indicators of Compromise (IOC)).

    ---

    FACT: Hosts work vs. Symbiote C2 server(s) per this line from a MUCH better article than the one used here from bradley13 per "configuration in the binary that used the git[.]bancodobrasil[.]dev domain as its C2 server" from https://www.intezer.com/blog/research/new-linux-threat-symbiote/ [intezer.com]

    & did I block that in my original posts here https://soylentnews.org/comments.pl?noupdate=1&sid=49835&page=1&cid=1253504#commentwrap [soylentnews.org] on this BOGUS sockpuppet upmodding yourselves shithole website (which also noted FIREWALLS are invaluable here too, per wildcards (or even IP address use, URL domain/subdomain too in many as well))?

    YES I DID! I was correct!

    FACT: hosts files block symbiote C2 servers which is all you really need to do to nullify their communication.

    FACT: Exfiltration isn't possible without orders either.

    FACT: Orders come from C2 servers!

    When I show people articles that debunk misinformation about COVID-19, the response is often that the articles are from the mainstream media and can't be trusted. It's the same principle, where the information is rejected on the basis of its source, without regard for content. - by dalek (15489) on Wednesday November 17, @06:14PM (#1197102)

    And what did you say to ME hypocrite?

    I'll believe a very prestigious scientific journal like Nature over the sketchy website you keep citing. - by dalek (15489) on Wednesday November 17, @11:30PM (#1197219)

    I showed real results doctors had on video stating it themselves.

    YET All you do is cite MSM VERY FAKE NEWS!

    Proven TONS of times to be so in fact along with their "fact checkers" !

    You're a mindless automaton, incapable of thinking for yourself. If you were capable of critical thinking and logical reasoning, you'd have already been aware that what you're posting is nonsense - by dalek (15489) on Friday November 05, @12:17AM (#1193524)

    I put up what PHD and MDs by the truckload literally let us see (not just YOUR MSM "russia, Russia, RUSSIA" disproven in COURTS vs. Trump very fake news)?

    Do as I say not as I do right dalek?

    You are a hypocrite BS artist that CONTRADICTS himself!

    More from your losing attempt @ DEBATING me (you = IGNORANT FOOL in this area of genetics & TOTALLY undereducated in it - whereas by COMPARISON I am not):

    Your rants about genetics are irrelevant - by dalek (15489) on Friday November 05, @02:17AM (#1193555)

    THIS IS ALL ABOUT GENETICS!

    WHAT IS mRNA after all?

    ANSWER = A part of protein synthesis involving mRNA, tRNA, & rRNA for the creation of DNA!

    IF RNA single helix strands JOIN improperly into a NEW double-helix DNA (via Guanine, Adenine, Cytosine & Thymine) it creates ERRORS (cancer is 1 possible bad one, mutations another etc.)

    See NHEJ below.

    dalek - have you taken any genetics coursework?

    I have & got A's (as my science elective requirement during my CS degreework)!

    vaccines don't contain graphene oxide.- by dalek (15489) on Tuesday October 26, @07:37AM (#1190563)

    1st of all, TONS of vaccines have used poisonous Graphene oxide (or dioxide) as ADJUVANTS over time.

    Secondly: ELECTRON MICROSCOPY EXPERT Dr. Young SHOWS POISONOUS GRAPHENE IN VACCINES ALSO:

    https://www.brighteon.com/9e58bf44-05e7-4b71-97e5-b243f6cf890c [brighteon.com]

    &

    https://www.brighteon.com/9fbd7735-b49d-4e31-a146-f67d7eb54d75 [brighteon.com]

    GRAPHENE OXIDE's in Pfizer, Moderna, Johnson & Johnson (Janssen) + AstraZeneca:

    https://www.brighteon.com/6d8fcfd7-4811-4e64-90c9-bd5585b59ff5 [brighteon.com]

    &

    A major cause of myocarditis, clotting, CANCER MALIGNANCY etc.? That's right: GRAPHENE OXIDE.

    COVID-19 vaccines do not cause cancer - by dalek (15489) on Tuesday October 26, @04:45AM (#1190535)

    Graphene Oxide Promotes Cancer Metastasis https://pubmed.ncbi.nlm.nih.gov/31877027/ [nih.gov]

    An Israeli study PROVES that the NHEJ (non-homologous end joining) mechanism in your cells is DAMAGED by SPIKE PROTEINS in the death vax & IT IS LINKED TO CANCER per https://naturalnews.com/2021-11-02-covid-vaccines-inhibit-dna-repair-cause-cancer.html [naturalnews.com]

    All FROM my +5 upmodded post on COVID killshots (which they HAVE proven to be on TONS of levels) https://soylentnews.org/comments.pl?noupdate=1&sid=46034&page=1&cid=1197563#commentwrap [soylentnews.org]

    you'll attack someone for extended periods of time whenever they show that you're wrong about something, which happens very frequently - by dalek (15489) on Wednesday October 06, @11:10PM (#1184989)

    LOL: Well, there's the BS you state WHERE YOU ATTACKED ME only to DESTROY YOURSELF for me - thank you, lol!

    HOW IRONIC!

    (Dalek "EXTERMINATED" not only by FACTS from experts in microscopy, but DALEK'S own WORDS he has to EAT, lol!)

    NOW THE "ICING ON THE CAKE" EXPOSING YOU, sockpuppeteer UPMODDING YOURSELF obviously + downmod bombing scumbag - RIGHT FROM YOU once more:

    Once this account is old enough to be eligible to moderate, I'll be happy to give you the spam mods you deserve - by dalek (15489) on Wednesday October 06, @11:10PM (#1184989)

    * THANKS FOR SHOWING US YOUR "MODUS OPERANDI" SOCKPUPPETEER troll! Fakename & all for a FAKE like you!

    APK

    P.S.=> THIS? This was just "too, Too, TOO EASY - just '2ez'" & it always IS vs. hypocrites like you, fakename... apk

  • (Score: 3, Touché) by DannyB on Thursday June 30 2022, @01:59PM (1 child)

    by DannyB (5839) Subscriber Badge on Thursday June 30 2022, @01:59PM (#1257179) Journal

    . . . than the heart of a Troll.

    --
    The lower I set my standards the more accomplishments I have.
    • (Score: 3, Interesting) by dwilson on Friday July 01 2022, @04:02PM

      by dwilson (2599) Subscriber Badge on Friday July 01 2022, @04:02PM (#1257367) Journal

      That sort of [wikipedia.org] depends [wikipedia.org] on [fandom.com] the [lifeinnorway.net] troll [dndbeyond.com], don't you think?

      --
      - D
  • (Score: 1) by shrewdsheep on Thursday June 30 2022, @08:28PM

    by shrewdsheep (5215) on Thursday June 30 2022, @08:28PM (#1257247)

    This was a heroic try, I fully applaud. I fear that little can be learned form this single case. But how to solve it? I believe many apes have to be transplanted with pig hearts first, before this can be a promising route. Let's hope there are still apes left on this world when we need them.

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