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posted by martyb on Friday September 16 2016, @02:40PM   Printer-friendly

Scientists at the University of Bath have created mice by injecting sperm into parthenogenotes:

Eggs can be 'tricked' into developing into an embryo without fertilisation, but the resulting embryos, called parthenogenotes, die after a few days because key developmental processes requiring input from sperm don't happen.

However, scientists from the Department of Biology & Biochemistry at the University of Bath have developed a method of injecting mouse parthenogenotes with sperm that allows them to become healthy baby mice with a success rate of up to 24 per cent. This compares to a rate of zero per cent for parthenogenotes or about two per cent for nuclear transfer cloning.

[...] The baby mice born as a result of the technique seem completely healthy, but their DNA started out with different epigenetic marks compared with normal fertilisation. This suggests that different epigenetic pathways can lead to the same developmental destination, something not previously shown.

The discovery has ethical implications for recent suggestions that human parthenogenotes could be used as a source of embryonic stem cells because they were considered inviable. It also hints that in the long-term future it could be possible to breed animals using non-egg cells and sperm. Although this is still only an idea, it could have potential future applications in human fertility treatment and for breeding endangered species.

Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes (open, DOI: 10.1038/ncomms12676) (DX)


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  • (Score: 2) by EvilSS on Friday September 16 2016, @03:00PM

    by EvilSS (1456) Subscriber Badge on Friday September 16 2016, @03:00PM (#402814)

    Wow, what will Logitech think up next?!

    Starting Score:    1  point
    Karma-Bonus Modifier   +1  

    Total Score:   2  
  • (Score: 2) by takyon on Friday September 16 2016, @04:26PM

    by takyon (881) <reversethis-{gro ... s} {ta} {noykat}> on Friday September 16 2016, @04:26PM (#402857) Journal

    Your favorite Logitech mouse, now with biological parts and real squeaking.

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    • (Score: 2) by Runaway1956 on Friday September 16 2016, @06:04PM

      by Runaway1956 (2926) Subscriber Badge on Friday September 16 2016, @06:04PM (#402889) Journal

      Gross. Which biological parts, exactly? Long, long ago, I positively hated the damned family cat. She was hunting, for mice of course, about the same time I was hunting for something I had misplaced. I reached into a cubbyhole, and closed my hand around some remaining biological parts. Just gross.

      Some things can still give you the creeps decades later.

      • (Score: 2) by Gaaark on Friday September 16 2016, @09:36PM

        by Gaaark (41) on Friday September 16 2016, @09:36PM (#402954) Journal

        Sounds like 'our' dog: pita!!!

        "A door is something a dog is always on the wrong side of"
        --Someone famous i can't be bothered googling

        ineedoutsidenowineedinsidenowineedoutsidenowineedinsidenowineedoutsidenowineedinsidenowineedoutsidenowineedinsidenowineedoutsidenowineedinsidenowineedoutsidenowineedinsidenowineedoutsidenowineedinsidenowineedoutsidenowineedinsidenowineedoutsidenowineedinsidenowineedoutsidenowineedinsidenow.....................

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