Researchers have developed a vaccine that may be effective at preventing many forms of the common cold (rhinovirus):
A mixture of 25 types of inactivated rhinovirus can stimulate neutralizing antibodies against all 25 in mice, and a mixture of 50 types can do the same thing in rhesus macaques. In this paper, antibodies generated in response to the vaccine were tested for their ability to prevent the virus from infecting human cells in culture. However, the vaccines were not tested for their ability to stop animals from getting sick.
"There are no good animal models of rhinovirus replication," Moore says. "The next step would be human challenge models with volunteers, which are feasible because the virus is not very pathogenic."
Emory has optioned the vaccine technology to a startup company, Meissa Vaccines, Inc., which is pursuing a product development plan with support from the National Institute of Allergy and Infectious Diseases' vaccine manufacturing services.
A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques (open, DOI: 10.1038/ncomms12838) (DX)
As the predominant aetiological agent of the common cold, human rhinovirus (HRV) is the leading cause of human infectious disease. Early studies showed that a monovalent formalin-inactivated HRV vaccine can be protective, and virus-neutralizing antibodies (nAb) correlated with protection. However, co-circulation of many HRV types discouraged further vaccine efforts. Here, we test the hypothesis that increasing virus input titres in polyvalent inactivated HRV vaccine may result in broad nAb responses. We show that serum nAb against many rhinovirus types can be induced by polyvalent, inactivated HRVs plus alhydrogel (alum) adjuvant. Using formulations up to 25-valent in mice and 50-valent in rhesus macaques, HRV vaccine immunogenicity was related to sufficient quantity of input antigens, and valency was not a major factor for potency or breadth of the response. Thus, we have generated a vaccine capable of inducing nAb responses to numerous and diverse HRV types.
(Score: 2) by jdavidb on Tuesday September 27 2016, @11:57PM
ⓋⒶ☮✝🕊 Secession is the right of all sentient beings
(Score: 0) by Anonymous Coward on Wednesday September 28 2016, @03:55PM
that's how socialism gets a foothold. then you get people like ledow evangelizing for their masters. it's fairly benevolent for a while but once they get everyone dependent and fully compliant they'll start making more and more decisions for people like the cattle they think you are. too many girls, everyone magically has boys. too many people, whoops noone gets pregnant. whoops we only meant that to last two generations. whoops we didn't mean for that flu shot to kill all the old people. whoops we didn't mean to make african women barren. whoops we didn't mean to alter the genes so new generations can never rebel. whoops we didn't mean to make genitalia non functional, or muscle mass much lower or intelligence or whatever those socialist scum decide to do for the good of "society".