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The regular consumption of salicylic acid, or its consumption in higher doses, could unexpectedly promote and prolong bacterial colonization, as shown by a joint study conducted by Monika Ehling-Schulz's group from the Institute of Microbiology, Vetmeduni Vienna, together with the research group of Fernanda Buzzola from the University of Buenos Aires. The research stays were in part funded by the Mobility Programme for Scientific and Technological Cooperation between Austria and Argentina.
Iron is an important trace element for the human body and plays an essential role in blood formation. The metabolism of many bacteria, including S. aureus, also depends on the availability of iron molecules. Salicylic acid forms complexes with iron ions in the blood and so deprives not only us but also the staphylococcal bacteria of this element. S. aureus modifies its metabolism if it obtains no or only insufficient iron. The microorganism reacts to the changed -- from its perspective, negative -- conditions through the intensified formation of a biofilm, a sort of layer of slime formed by the aggregation of individual bacteria, as Tom Grunert of the Institute for Microbiology at Vetmeduni Vienna explains. The accelerated biofilm production allows the bacteria to survive for an even longer period under unfavourable living conditions.
This increased biofilm formation is promoted by the regular or increased consumption of salicylic acid. As pain relief medication, this compound is usually not taken regularly. However, it also is a component of anti-acne preparations and certain exfoliate products, which are often used for a longer period of time. Since salicylic acid is found in fruits and vegetables, people who follow a mostly vegetarian diet might also affected. "These people consume a small dose of the substance virtually every day," says Grunert. The use of certain medications further increases the iron limitation. Taken orally, salicylic acid enters the blood circulation and forms there complexes with the iron ions.
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(Score: 3, Informative) by seeprime on Sunday February 05 2017, @05:02AM
You didn't say how old you are now. I'm guessing that you don't exercise due to feeling like shit. I feel the same way. I also have ringing in my ears and am cold a lot. It's called growing older. At least four times a week I exercise for 15 minutes or more. I stretch daily, as my back gets weird otherwise. Try moving around more. It won't help your ear-ringing, but it will warm you up for a while and help you feel a bit better for the rest of the day. If it's legal where you live, weed would be a big help, it's a very good pain reliever, for the aches and pains that you describe.
(Score: 0) by Anonymous Coward on Sunday February 05 2017, @05:31AM
Hi, original AC... I'm mid-forties now and I stopped exercising a few years ago but I'm not overweight. I tried weed a few times but I'm not able to function on it at all, it makes me very sleepy and kills my concentration. I'd really like to know if the aspirin/tylenol intake is dangerous. The aspirin tablets are 375mg (taking >10 per day) and the tylenol are 325mg (under 4g per day). It seems like I urinate a lot (and often) but I also drink a lot of water so it's usually light yellow or nearly clear most days. I've always been a self-starter and tried not to allow my chronic pain become an excuse to not work but I feel like I'm really slowing down. In the past six months I've been sleeping much longer on the weekends and Monday morning hits me like a train. This story has really got me worried that I may be in real trouble.
(Score: 2) by Azuma Hazuki on Sunday February 05 2017, @05:50AM
You've got salicylate poisoning, and you're lucky you haven't had a massive hemorrhage in your brain. Your liver is also not going to thank you with that dose of paracetamol.
I'm not sure what else can be done for the pain though :( Maybe see if you can get someone to make you "cannabis tincture" instead of smoking the stuff?
I am "that girl" your mother warned you about...
(Score: 0) by Anonymous Coward on Sunday February 05 2017, @12:38PM
+1 for the Weed option
When you get to the point you are at you need to find some dope dealers, offer to take their unwanted leaves, learn how to get the good stuff out (boiling usually), learn how to make cookies or cake, and learn how much you need to bake yourself every day. (Bake yourself. Geddit?)
You have passed the point where standard medicines can help. Go to weed.
(Score: 0) by Anonymous Coward on Sunday February 05 2017, @12:41PM
... or find someone who bakes green cookies who will take some green notes for green baked goods
Is cheaper to just do it yourself of course
(Score: 2, Touché) by Anonymous Coward on Sunday February 05 2017, @07:47AM
Have you considered praying away the pain? I hear this is an effective treatment for some types of bodily perversions.
(Score: 2) by sjames on Sunday February 05 2017, @08:20AM
That sounds like a lot of Tylenol, especially as a chronic dose. That stuff can really kill your liver.
Perhaps it would be worth while to try a low or moderate THC weed on the weekends so you can spend some time clear of the Tylenol and aspirin.
(Score: 1) by purple_cobra on Tuesday February 07 2017, @04:12PM
I am not a doctor, so please see one before acting on anything here:
Aspirin will thin your blood, so if you have any issues that cause bleeding, e.g. haemorrhoids, varices, etc, regular aspirin will make those worse. Aspirin is also a non-steroidal anti-inflammatory drug (NSAID) and those tend not to be good for your kidneys, as mentioned by Azuma Hazuki; she also mentioned salicylate poisoning and after reading a little about that, I have to agree that sounds possible so please cut back on that as much as you can and see your doctor at your earliest opportunity. Without wishing to alarm you, this can be fatal in the longer term so please do not just leave it to chance.
If you're taking =4g paracetamol (Tylenol) per day, are otherwise healthy and not taking any other medication, that shouldn't do you any harm; I've been prescribed a paracetamol/codeine mix that amounts to 4g paracetamol per day and no changes were noted on blood tests for kidney or liver problems, but that bit about being "otherwise healthy and not taking any other medication" is hugely important and is also why you should get this checked out by a doctor. Combined with the aspirin this may well be causing you harm.
Here in the UK, pain management specialists are part of the anaesthetics team but I have no idea where what I presume is a US healthcare patient would - or could - access that care. For neuropathic (nerve-related) pain, they would generally prescribe something like low-dose amitriptyline or gabapentin, possibly with a mild opioid for the initial couple of weeks as they take a while to have any effect.
I urge you to see a doctor as soon as possible to both optimise your pain relief and to ensure your current medication regime hasn't done any lasting damage. Pain management has come a long way and you can be treated more effectively and more safely.
(Score: 2) by mcgrew on Sunday February 05 2017, @07:58PM
Tinnitis isn't age-related, it's caused by other factors, such as certain drugs (aspirin is one, the tinnitus is temporary) and long-term exposure to loud noise, which causes permanent tinnitis.
I'm 64 and my ears never ring.
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