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The regular consumption of salicylic acid, or its consumption in higher doses, could unexpectedly promote and prolong bacterial colonization, as shown by a joint study conducted by Monika Ehling-Schulz's group from the Institute of Microbiology, Vetmeduni Vienna, together with the research group of Fernanda Buzzola from the University of Buenos Aires. The research stays were in part funded by the Mobility Programme for Scientific and Technological Cooperation between Austria and Argentina.
Iron is an important trace element for the human body and plays an essential role in blood formation. The metabolism of many bacteria, including S. aureus, also depends on the availability of iron molecules. Salicylic acid forms complexes with iron ions in the blood and so deprives not only us but also the staphylococcal bacteria of this element. S. aureus modifies its metabolism if it obtains no or only insufficient iron. The microorganism reacts to the changed -- from its perspective, negative -- conditions through the intensified formation of a biofilm, a sort of layer of slime formed by the aggregation of individual bacteria, as Tom Grunert of the Institute for Microbiology at Vetmeduni Vienna explains. The accelerated biofilm production allows the bacteria to survive for an even longer period under unfavourable living conditions.
This increased biofilm formation is promoted by the regular or increased consumption of salicylic acid. As pain relief medication, this compound is usually not taken regularly. However, it also is a component of anti-acne preparations and certain exfoliate products, which are often used for a longer period of time. Since salicylic acid is found in fruits and vegetables, people who follow a mostly vegetarian diet might also affected. "These people consume a small dose of the substance virtually every day," says Grunert. The use of certain medications further increases the iron limitation. Taken orally, salicylic acid enters the blood circulation and forms there complexes with the iron ions.
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(Score: 1) by purple_cobra on Tuesday February 07 2017, @04:12PM
I am not a doctor, so please see one before acting on anything here:
Aspirin will thin your blood, so if you have any issues that cause bleeding, e.g. haemorrhoids, varices, etc, regular aspirin will make those worse. Aspirin is also a non-steroidal anti-inflammatory drug (NSAID) and those tend not to be good for your kidneys, as mentioned by Azuma Hazuki; she also mentioned salicylate poisoning and after reading a little about that, I have to agree that sounds possible so please cut back on that as much as you can and see your doctor at your earliest opportunity. Without wishing to alarm you, this can be fatal in the longer term so please do not just leave it to chance.
If you're taking =4g paracetamol (Tylenol) per day, are otherwise healthy and not taking any other medication, that shouldn't do you any harm; I've been prescribed a paracetamol/codeine mix that amounts to 4g paracetamol per day and no changes were noted on blood tests for kidney or liver problems, but that bit about being "otherwise healthy and not taking any other medication" is hugely important and is also why you should get this checked out by a doctor. Combined with the aspirin this may well be causing you harm.
Here in the UK, pain management specialists are part of the anaesthetics team but I have no idea where what I presume is a US healthcare patient would - or could - access that care. For neuropathic (nerve-related) pain, they would generally prescribe something like low-dose amitriptyline or gabapentin, possibly with a mild opioid for the initial couple of weeks as they take a while to have any effect.
I urge you to see a doctor as soon as possible to both optimise your pain relief and to ensure your current medication regime hasn't done any lasting damage. Pain management has come a long way and you can be treated more effectively and more safely.