Tapping the ocean as a source of natural products:
Despite this significant role, research into the diversity of microorganisms found in the ocean has thus far been only rudimentary. So, a group of researchers led by Shinichi Sunagawa, Professor of Microbiome Research, is working closely with Jörn Piel's group to investigate this diversity. Both groups are at the Institute of Microbiology at ETH Zurich.
To detect new natural products made by bacteria, Sunagawa and his team examined publicly available DNA data from 1,000 water samples collected at different depths from every ocean region in the world. The data came from such sources as ocean expeditions and observation platforms positioned out at sea.
Thanks to modern technologies like environmental DNA (eDNA) analysis, it has become easier to search for new species and discover which known organisms can be found where. But what is hardly known at all is what special effects the marine microorganisms offer -- in other words, what chemical compounds they make that are important for interactions between organisms. In the best-case scenario, such compounds would benefit humans as well. Underpinning the research is the assumption that the ocean microbiome harbours great potential for natural products that could prove beneficial, for instance for their antibiotic properties.
The extracted eDNA present in the samples was sequenced by the original researchers of the various expeditions. By reconstructing entire genomes on the computer, the scientists succeeded in decrypting the encoded information -- the blueprints for proteins. Finally, they consolidated this new data together with the existing 8,500 genome data sets for marine microorganisms in a single database.
This gave them 35,000 genomes to draw on when searching for new microbial species and, in particular, for promising biosynthetic gene clusters (BGCs). A BGC is a group of genes that provide the synthetic pathway for a natural product.
In this genome data, the researchers detected not only many potentially useful BGCs -- some 40,000 in all -- but also previously undiscovered species of bacteria belonging to the phylum Eremiobacterota. This group of bacteria had been known to exist only in terrestrial environments and didn't exhibit any special biosynthetic diversity.
Sunagawa and his team named a new family of these bacteria as Eudoremicrobiaceae, and also were able to demonstrate that these bacteria are common and widespread: one species belonging to this family, Eudoremicrobium malaspinii, accounts for up to 6 percent of all bacteria present in certain areas of the ocean.
"The relatives in the ocean possess what for bacteria is a giant genome. Fully decrypting it was technically challenging because the organisms had not been cultivated before," Sunagawa says. Moreover, the new bacteria turned out to belong to the group of microorganisms that boasts the highest BGC diversity of all the samples examined. "As things stand, they are the most biosynthetically diverse family in the oceanic water column," he says. The researchers looked at two Eudoremicrobiaceae BGCs in detail. One was a gene cluster containing the genetic code for enzymes that, according to Sunagawa, have never been found in this constellation in a bacterial BGC before. The other examined example was a bioactive natural product that inhibits a proteolytic enzyme.
Journal Reference:
Paoli, Lucas, Ruscheweyh, Hans-Joachim, Forneris, Clarissa C., et al. Biosynthetic potential of the global ocean microbiome [open], Nature (DOI: 10.1038/s41586-022-04862-3)
(Score: 1) by khallow on Friday July 01 2022, @12:13PM
What small number of people? Neither your or my opinions are in any way rare. And I suppose we're just going to gloss over such things as a decades long pattern of dishonesty in the climate change argument or the considerable economic and political power that has managed to outspend Big Oil for the entire 25 year period.
My take is that we're already well on our way - a big part of the reason human fertility is declining is because people globally are becoming more wealthy and prosperous.
Irrelevant. An unproductive fight for life is not life extension.
You just don't get it. It doesn't matter what a bunch of envious, clueless idiots complain about. They'll be envious and clueless about something different tomorrow. And those demands for "fix our problems here" are merely signaling just how clueless and impotent they really are.
And yet, Russia logistics had severe tire problems when it mattered. Corruption blows back. The more of it your country has, the more obvious its effects become.
You won't find the present massive improvement in the human condition anywhere in human history. And we still have no reason to care about wealth disparity. It's a phantom menace.
The potential for "masses to abuse" hasn't been exercised in the real world. After all, every developed world country is moving towards greater environmental awareness and preparation - such as that growing amount of protected land you downplayed earlier. Keep in mind that no serious environmental problem aside from habitat destruction (sorry, hot house Earth needs some evidence) has been mentioned in this thread - and the developed world is addressing that.