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from the big-pharma-ain't-gonna-like-this dept.
A team from Newcastle University, UK, has shown that Type 2 diabetes is caused by fat accumulating in the pancreas -- and that losing less than one gram of that fat through weight loss reverses the diabetes.
Affecting two and a half million people in the UK -- and on the increase -- Type 2 diabetes is a long-term condition caused by too much glucose, a type of sugar, in the blood.
...
In a trial, 18 people with Type 2 diabetes and 9 people who did not have diabetes were measured for weight, fat levels in the pancreas and insulin response before and after bariatric surgery. The patients with Type 2 diabetes had been diagnosed for an average of 6.9 years, and all for less than 15 years.The people with Type 2 diabetes were found to have increased levels of fat in the pancreas.
The participants in the study had all been selected to have gastric bypass surgery for obesity and were measured before the operation then again eight weeks later. After the operation, those with Type 2 diabetes were immediately taken off their medication.
Both groups lost the same amount of weight, around 13% of their initial body weight. Critically, the pool of fat in the pancreas did not change in the non-diabetics but decreased to a normal level in those with Type 2 diabetes.
Good news for people with Type 2 diabetes and puts more importance on sticking to New Year's resolutions to lose weight.
(Score: 2) by rleigh on Saturday December 05 2015, @12:11AM
Brown fat is primarily found on the upper back; not really around visceral organs--it's pretty much all white there. Since its purpose is heat generation, you wouldn't want it to occur internally anyway--it would cause heat shock and damage or even death! When it gets going it can put out some serious heat--anyone remember painful searing heat over their back after playing in the cold as a child? Incidentally, one study I read recently was sleeping in the cold to trigger brown adipose tissue heat generation so it burns fat while you sleep with apparently beneficial effects.
Cardio will mobilise fat stores once you've used up all the stored glycogen. Since this is triggered by a hormone (glucagon), its effects are systemic, so it will act on all adipose tissue, be it subepithelial or visceral. That's also why it was lost after the gastric bypass--since you're now starting to burn fat as a result of the food intake reduction. Their weight may have reduced massively overall, but proportionally only a small part of that is from visceral fat around internal organs. So it takes a significant change to your metabolism to shift it.