SoylentNews is people
SoylentNews
A story from scienceblog.com looks at a novel treatment and prevention of tooth decay:
The bacteria that live in dental plaque and contribute to tooth decay often resist traditional antimicrobial treatment, as they can "hide" within a sticky biofilm matrix, a glue-like polymer scaffold.
A new strategy conceived by University of Pennsylvania researchers took a more sophisticated approach. Instead of simply applying an antibiotic to the teeth, they took advantage of the pH-sensitive and enzyme-like properties of iron-containing nanoparticles to catalyze the activity of hydrogen peroxide, a commonly used natural antiseptic. The activated hydrogen peroxide produced free radicals that were able to simultaneously degrade the biofilm matrix and kill the bacteria within, significantly reducing plaque and preventing the tooth decay, or cavities, in an animal model.
"Even using a very low concentration of hydrogen peroxide, the process was incredibly effective at disrupting the biofilm," said Hyun (Michel) Koo, a professor in the Penn School of Dental Medicine's Department of Orthodontics and divisions of Pediatric Dentistry and Community Oral Health and the senior author of the study, which was published in the journal Biomaterials [DOI: 10.1016/j.biomaterials.2016.05.051]. "Adding nanoparticles increased the efficiency of bacterial killing more than 5,000-fold."
The paper's lead author was Lizeng Gao, a postdoctoral researcher in Koo's lab. Coauthors were Yuan Liu, Dongyeop Kim, Yong Li and Geelsu Hwang, all of Koo's lab, as well as David Cormode, an assistant professor of radiology and bioengineering with appointments in Penn's Perelman School of Medicine and School of Engineering and Applied Science, and Pratap C. Naha, a postdoctoral fellow in Cormode's lab.
The work built off a seminal finding by Gao and colleagues, published in 2007 in Nature Nanotechnology [DOI: 10.1038/nnano.2007.260], showing that nanoparticles, long believed to be biologically and chemically inert, could in fact possess enzyme-like properties. In that study, Gao showed that an iron oxide nanoparticle behaved similarly to a peroxidase, an enzyme found naturally that catalyzes oxidative reactions, often using hydrogen peroxide.
(Score: 3, Informative) by takyon on Thursday July 28 2016, @01:34PM
Couldn't this screw up the microbiome in your mouth?
[SIG] 10/28/2017: Soylent Upgrade v14 [soylentnews.org]
(Score: 0) by Anonymous Coward on Thursday July 28 2016, @02:49PM
My thought exactly, killing bacteria willy-nilly seems likely to have some consequences.
I like sweet things, but also know that sugar promotes tooth decay. So I generally have my sweet in the evening, and then brush my teeth shortly after.
(Score: 1) by Francis on Friday July 29 2016, @04:00AM
Considering that dentists have been implanting known neurotoxins in people's mouths for centuries now and insist upon lying about it, I'd take anything they say with a grain of salt. Those "amalgam" fillings that they've been using since the 19th century aren't so much an amalgam as they are mercury. They're roughly 50% mercury by volume and they don't call them that because people would object to having that crap put in their mouths where it can and does leech into the body.