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posted by cmn32480 on Monday August 01 2016, @10:31AM   Printer-friendly
from the ah-crap dept.

Although the incidence of hospital-onset Clostridium difficile infection (CDI) may be declining slightly, the Centers for Disease Control and Prevention estimates that close to half a million cases still occur in the United States each year. Multiple relapses also remain common, with approximately 30 percent of patients experiencing at least one recurrence two to four weeks after completing standard antibiotic therapy. Patients who have one recurrence are at high risk of multiple additional recurrences, with a 60 percent chance of relapse after the third recurrence. These patients tend to have poor outcomes and present major clinical challenges.

Seres Therapeutics ($MCRB) has suffered a sizable setback to its microbiome R&D ambitions. In a Phase II trial, the oral microbiome therapeutic SER-109 failed to outperform a placebo in terms of cutting the risk of Clostridium difficile infection (CDI), leaving the biotech scraping through the results in search [of] a path forward for the program.

[...] The fallout from the setback could extend well beyond Seres, which has been held up as an example of the potential of the microbiome sector, both from a financial and therapeutic perspective. In the good times, such as after Seres pulled off a $134 million IPO, the company has delivered a sector-wide boost to the nascent field.

http://www.mayoclinic.org/medical-professionals/clinical-updates/digestive-diseases/study-confirms-safety-efficacy-of-ser-109
http://www.fiercebiotech.com/biotech/seres-shares-crash-after-microbiome-drug-flunks-phii
https://en.wikipedia.org/wiki/Clostridium_difficile_colitis


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  • (Score: 0) by Anonymous Coward on Monday August 01 2016, @06:38PM

    by Anonymous Coward on Monday August 01 2016, @06:38PM (#382737)

    No a poop-to-cranium transplant has been show to improve reasoning skills in 87% of presidential candidates.