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A well-known rheumatoid arthritis medication containing the active agent adalimumab, a therapeutic human monoclonal antibody, is also effective for treating non-infectious uveitis, a rare eye disease. This has now been discovered by an international research group, in which MedUni Vienna was also involved with significant participation by Talin Barisani-Asenbauer of the Center for Pathophysiology, Infectiology & Immunology and the Laura Bassi Center at MedUni Vienna. The results of the VISUAL-I study have now been published in the leading journal New England Journal of Medicine.
"We were able to prospectively demonstrate for the very first time that non-infectious uveitis can also be successfully treated with a cortisol-free medication. That will significantly improve the management of uveitis patients who have only partially responded to corticosteroids, need a corticosteroid sparing therapy or who are unsuitable for treatment with corticosteroids," explains Barisani-Asenbauer. The biologic medication adalimumab has long been used to treat rheumatic diseases and has to be injected subcutaneously every two weeks. For sufferers, steroid-free means there are fewer side-effects, so that it can be used over a longer period of time.
(Score: 0) by Anonymous Coward on Friday October 21 2016, @09:41PM
Check you dosage to see if it matches the study:
[Patients received] adalimumab (a loading dose of 80 mg followed by a dose of 40 mg every 2 weeks)
It's also possible that your immune system is rejecting the adalimumab (anti-idiotypic) or TNF is not a major factor in your eye inflammation.
http://www.nejm.org/doi/10.1056/NEJMoa1509852 [nejm.org]
https://en.wikipedia.org/wiki/Idiotopes [wikipedia.org]