Stories
Slash Boxes
Comments

SoylentNews is people

posted by janrinok on Sunday October 23 2016, @06:31PM   Printer-friendly
from the fishy dept.

The research team of Dr. Caghan Kizil at the DFG-Center for Regenerative Therapies Dresden (CRTD) - Cluster of Excellence at the TU Dresden, achieved a major advance in Alzheimer's research. They showed how a diseased vertebrate brain can naturally react to Alzheimer's pathology by forming more neurons. Two proteins (Interleukin-4 and STAT6) have been identified to be relevant for this process. This is a big step towards the understanding, prevention or even healing of Alzheimer's disease – a disease with about 170,000 new cases diagnosed every year in Germany. The results have been published in the scientific journal Cell Reports this week.

[...] The study of the laboratory of Dr. Caghan Kizil used the animal model zebrafish, which can regenerate their brain. Zebrafish have an extensive ability to replenish the lost neurons after various types of damage, and the team led by Dr. Kizil showed that it can also do so after Alzheimer-like neurodegeneration. This is an ability humans do not have. Evolutionarily, the zebrafish and human beings are very similar: the cell types in the zebrafish brain and their physiological roles are very similar to humans, and more than 80 percent of the genes humans have are identical in the zebrafish.

Therefore, zebrafish are an ideal model for studying complex diseases of humans in a very simplistic way. "We believe that understanding how zebrafish can cope with neurodegeneration would help us to design clinical therapy options for humans, such as for Alzheimer's disease. Within this study, we observed Alzheimer-like conditions in the fish brain. We found that zebrafish can impressively increase the neural stem cell proliferation and formation of new neurons even after Alzheimer's-like pathology. This is amazing because to treat Alzheimer's we need to generate more neurons. And this all starts with neural stem cell proliferation, which fails in our diseased brains", Caghan Kizil explains.

This study has shown that Alzheimer's disease symptoms can be recapitulated in the zebrafish brain using a short section of human APP protein that is a hallmark of Alzheimer's disease (Amyloid-β42). This protein part causes the death of neurons, inflammation, loss of neuronal connections and deficits in memory formation in zebrafish. Caghan Kizil's research group including the lead author involved in the study, Prabesh Bhattarai, found that the immune-related molecule Interleukin-4 (which is also present in the human brain) is produced by the immune cells and dying neurons in the fish brain.


Original Submission

 
This discussion has been archived. No new comments can be posted.
Display Options Threshold/Breakthrough Mark All as Read Mark All as Unread
The Fine Print: The following comments are owned by whoever posted them. We are not responsible for them in any way.
  • (Score: -1, Troll) by Anonymous Coward on Sunday October 23 2016, @06:42PM

    by Anonymous Coward on Sunday October 23 2016, @06:42PM (#417917)

    he wanted to love me but i loved him harder

    Starting Score:    0  points
    Moderation   -1  
       Troll=1, Total=1
    Extra 'Troll' Modifier   0  

    Total Score:   -1