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Among older women residing in nursing homes, administration of cranberry capsules compared with placebo resulted in no significant difference in presence of bacteriuria plus pyuria (presence of bacteria and white blood cells in the urine, a sign of urinary tract infection [UTI]), or in the number of episodes of UTIs over 1 year, according to a study published online by JAMA. The study is being released to coincide with its presentation at IDWeek 2016.
Urinary tract infection is the most commonly diagnosed infection among nursing home residents. Bacteriuria is prevalent in 25 percent to 50 percent of women living in nursing homes, and pyuria is present in 90 percent of those with bacteriuria. Cranberry capsules are an understudied, nonantimicrobial prevention strategy used in this population. Manisha Juthani-Mehta, M.D., of the Yale School of Medicine, New Haven, Conn., and colleagues randomly assigned 185 women (average age, 86 years; with or without bacteriuria plus pyuria at study entry) residing in nursing homes to two oral cranberry capsules, each capsule containing 36 mg of the active ingredient proanthocyanidin (i.e., 72 mg total, equivalent to 20 ounces of cranberry juice) or placebo administered once a day.
Another folk remedy bites the dust?
(Score: 0, Troll) by Francis on Sunday October 30 2016, @09:49PM
Not necessarily. It might mean that the active ingredient in the pill isn't making its way into the small intestine when it's taken as a pill.
That wouldn't be the first time changing the delivery mechanism changed the efficacy. That's a problem that comes up fairly often when generic medications are put into different pill shrouds than the name brand you sometimes get slightly different reactions from patients.
A better way to conduct the experiment would probably be to take the ingredient they're looking at and dissolve it into water at roughly the expected concentration of cranberry juice. That way, it's more likely to behave like the real thing. If that works, then they can consider testing it in pill form. But as it is, they don't necessarily know if the ingredient didn't work or if it didn't get delivered appropriately.
(Score: 0) by Anonymous Coward on Monday October 31 2016, @04:02AM
Reading comprehension much? The person I quoted was claiming the benefit had to do with increased urine to flush out bacteria. What does the small intestine have to do with the bladder and urine?
(Score: -1, Troll) by Anonymous Coward on Monday October 31 2016, @04:08AM
If you're going to mod me a troll, you could at least read my post before doing so. I think it's pretty fucking obvious what the connection between my post and the ones I'm responding to is.