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posted by martyb on Monday October 31 2016, @08:28AM   Printer-friendly
from the round-and-round-the-mulberry-bush dept.

"The beneficial effects of rutin on BAT-mediated [brown adipose tissue] metabolic improvement have evoked a substantial interest in the potential treatment for obesity and its related diseases, such as diabetes," said Wan-Zhu Jin, Ph.D., a researcher involved in the work from the Institute of Zoology at the Chinese Academy of Sciences in Beijing, China. "In line with this idea, discovery of more safe and effective BAT activators is desired to deal with obesity and its related diseases."

To make their discovery, Jin and colleagues used both genetically obese mice and mice with diet-induced obesity as models. These mice were fed a regular diet, and supplemental rutin (1 mg/ml) was added to their drinking water. Rutin treatment significantly reduced adiposity, increased energy expenditure, and improved glucose homeostasis in both the genetically obese mice and the mice with diet-induced obesity. Specifically, the researchers found that rutin directly binds to and stabilizes SIRT1 (NAD-dependent deacetylase sirtuin-1), leading to hypoacetylation of PGC1α protein, which stimulates Tfam transactivation and eventually augments mitochondrial number and UCP1 activity in BAT. Rutin functions as a cold mimetic through activating a SIRT1-PGC1α-Tfam signaling cascade and increasing mitochondrial number and UCP1 activity in BAT. Rutin also induced brown-like (beige) adipocyte formation in subcutaneous adipose tissue in both obesity mouse models.

An abstract is available:Rutin ameliorates obesity through brown fat activation. The FASEB Journal, 2016; DOI: 10.1096/fj.201600459RR; full article is pay-walled.

Mulberry trees grow wild in many places, even in Central Park.


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  • (Score: 2) by ikanreed on Monday October 31 2016, @03:58PM

    by ikanreed (3164) Subscriber Badge on Monday October 31 2016, @03:58PM (#420908) Journal

    So him getting yanked into a senate committee hearing on bogus medicine didn't actually cause him to tone it down afterwards?

    That's sad to hear.

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  • (Score: 0) by Anonymous Coward on Monday October 31 2016, @07:36PM

    by Anonymous Coward on Monday October 31 2016, @07:36PM (#421016)

    It did.
    But if he went completely factual his show would no longer be entertaining.
    The guy gave Trump a pass on his bullshit medical report. So he's still a joke, just not quite as bad of a joke.