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from the the-fountain-of-eternal-youth dept.
An end to grey hair and crows-feet could be just 10 years away after scientists showed it is possible to reverse ageing in animals.
Using a new technique which takes adult cells back to their embryonic form, US researchers at the Salk Institute in California, showed it was possible to reverse ageing in mice, allowing the animals to not only look younger, but live for 30 per cent longer.
The technique involves stimulating four genes which are particularly active during development in the womb. It was also found to work to turn the clock back on human skin cells in the lab, making them look and behave younger.
Scientists hope to eventually create a drug which can mimic the effect of the found genes which could be taken to slow down, and even reverse the ageing process. They say it will take around 10 years to get to human trials.
There is also a study paper.
(Score: 0) by Anonymous Coward on Saturday December 17 2016, @06:55AM
Figure 3
Establishment of In Vivo Induction Protocol in 4F Mice
(A) Body weight of 4F mice upon continuous administration of doxycycline (−Dox n = 11; +Dox n = 26).
Figure 4
Extension of Lifespan and Prevention of Age-Associated Phenotypes by In Vivo Induction of Oct4, Sox2, Klf4, and c-Myc
(A) Body weight of LAKI and LAKI 4F mice upon cyclic doxycycline administration. LAKI (−Dox n = 20; +Dox n = 13) and LAKI 4F (−Dox n = 18; +Dox n = 15).
(G) ECG analysis in LAKI 4F mice upon cyclic doxycycline administration (−Dox n = 4; +Dox n = 4). Heart rate represented as beats per minute (bpm). ∗p 0.05, ∗∗p 0.001, and ∗∗∗∗p 0.0001 according to one-way ANOVA with Bonferroni correction.
Figure 7
Improved Resistance to Metabolic Disease and Skeletal Muscle Injury in Aged WT Animals by In Vivo Reprogramming
(B) Glucose tolerance test (GTT) in 12-month-old WT 4F mice following beta cell ablation by low dose STZ (−Dox n = 6; +Dox n = 6). ∗∗p 0.01 and ∗∗∗p = 0.0005 according to two-tailed Student’s t test.
(G) Quantification of fiber cross-sectional area frequency distribution and percentage of central nucleated fibers in muscle sections of 12-month-old WT 4F mice following muscle injury by CTX injection (−Dox n = 4; +Dox n = 4). ∗∗p 0.001 according to two-tailed Student’s t test.
Figure S3
Effect of Long-Term In Vivo Cyclic Induction of Oct4, Sox2, Klf4, and c-Myc in Mice Carrying One and Two Copies of OSKM and rtTA Cassette, Related to Figure 3
(A) Body weight of wild-type (WT) and 4F mice carrying single copy of OSKM and rtTA cassette upon cyclic administration of doxycycline. WT (n = 5) and 4F (n = 3).
Figure S7
Analysis of Pancreatic Function and Skeletal Muscle Regeneration in Wild-Type Mice, Related to Figure 7
(A) Glucose tolerance test (GTT) in 2-month and 12-month old WT mice following beta cell ablation by low dose (50 mg/kg) STZ (2-month WT n = 3; 12-month WT n = 3).
(D) GTT in 12-month old WT mice following doxycycline and beta cell ablation by low dose (50 mg/kg) STZ (-Dox n = 5; +Dox n = 5).
(I) Quantification of percentage of central nucleated fibers in muscle sections of 12-month old WT mice following doxycycline treatment and muscle injury by CTX injection (-Dox n = 3; +Dox n = 3).
They killed these mice to death!
(Score: 0) by Anonymous Coward on Saturday December 17 2016, @05:40PM
Thanks, I was on mobile and saw no sample sizes for the first fig. No blinding though? Also the naziesque desensitization these grad students go through is pretty scary. I know, they did it to me. Decapitating dozens of rats who think you are their friend overnight etc.
(Score: 0) by Anonymous Coward on Saturday December 17 2016, @07:50PM
This is the only mention of blinding, it also includes an example of the BS sample size reporting:
More BS sample size reporting:
Also, we see the usual x causes y claims with no scatter plots to show us the relationship between these phenomena
I wouldn't worry too much about "the rich" hoarding this great medicine described here.