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Scientists Reverse Ageing in Mammals and Predict Human Trials Within 10 Years

posted by janrinok on Saturday December 17 2016, @05:57AM   Printer-friendly
from the the-fountain-of-eternal-youth dept.

Phoenix666 writes:

An end to grey hair and crows-feet could be just 10 years away after scientists showed it is possible to reverse ageing in animals.

Using a new technique which takes adult cells back to their embryonic form, US researchers at the Salk Institute in California, showed it was possible to reverse ageing in mice, allowing the animals to not only look younger, but live for 30 per cent longer.

The technique involves stimulating four genes which are particularly active during development in the womb. It was also found to work to turn the clock back on human skin cells in the lab, making them look and behave younger.

Scientists hope to eventually create a drug which can mimic the effect of the found genes which could be taken to slow down, and even reverse the ageing process. They say it will take around 10 years to get to human trials.

There is also a study paper.

Original Submission

 
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  • (Score: 0) by Anonymous Coward on Saturday December 17 2016, @05:40PM

    by Anonymous Coward on Saturday December 17 2016, @05:40PM (#442470)

    Thanks, I was on mobile and saw no sample sizes for the first fig. No blinding though? Also the naziesque desensitization these grad students go through is pretty scary. I know, they did it to me. Decapitating dozens of rats who think you are their friend overnight etc.

  • (Score: 0) by Anonymous Coward on Saturday December 17 2016, @07:50PM

    by Anonymous Coward on Saturday December 17 2016, @07:50PM (#442499)

    This is the only mention of blinding, it also includes an example of the BS sample size reporting:

    For quantification of histological and immunohistochemistry analysis, three sections per tissue from 3-5 animals were analyzed using ImageJ (NIH). All quantifications were performed blinded.

    More BS sample size reporting:

    All of the data are presented as the mean ± SEM and represent a minimum of three independent experiments.

    Also, we see the usual x causes y claims with no scatter plots to show us the relationship between these phenomena

    Highlights
    - Partial reprogramming erases cellular markers of aging in mouse and human cells
    - Induction of OSKM in progeria mice ameliorates signs of aging and extends lifespan
    - In vivo reprogramming improves regeneration in 12-monthold wild-type mice

    I wouldn't worry too much about "the rich" hoarding this great medicine described here.