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posted by Fnord666 on Friday December 30 2016, @09:16PM   Printer-friendly
from the take-before-having-the-chicken-tartar dept.

Researchers from The University of Texas Medical Branch at Galveston have developed a vaccine against salmonella poisoning designed to be taken by mouth. The findings are detailed in an article published in Frontiers in Cellular and Infection Microbiology.

In earlier studies, the UTMB researchers developed potential vaccines from three genetically mutated versions of the salmonella bacteria, that is Salmonella Typhimurium, that were shown to protect mice against a lethal dose of salmonella. In these studies, the vaccines were given as an injection.

[...] There is no vaccine currently available for salmonella poisoning. Antibiotics are the first choice in treating salmonella infections, but the fact that some strains of salmonella are quickly developing antibiotic resistance is a serious concern. Another dangerous aspect of salmonella is that it can be used as a bioweapon -- this happened in Oregon when a religious cult intentionally contaminated restaurant salad bars and sickened 1,000 people.

[...] Salmonella is responsible for one of the most common food-borne illnesses in the world. In the US alone, the Centers for Disease Control and Prevention estimates that there are about 1.4 million cases with 15,000 hospitalizations and 400 deaths each year. It is thought that for every reported case, there are approximately 39 undiagnosed infections. Overall, the number of salmonella cases in the US has not changed since 1996.

Tatiana E. Erova, et al. Protective Immunity Elicited by Oral Immunization of Mice with Salmonella enterica Serovar Typhimurium Braun Lipoprotein (Lpp) and Acetyltransferase (MsbB) Mutants. Frontiers in Cellular and Infection Microbiology, 2016; 6 DOI: 10.3389/fcimb.2016.00148


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  • (Score: 0) by Anonymous Coward on Saturday December 31 2016, @03:57AM

    by Anonymous Coward on Saturday December 31 2016, @03:57AM (#447742)

    Salmonella is a bacteria. "Vaccine" does not work against bacterial infection.

  • (Score: 1) by RandomFactor on Saturday December 31 2016, @04:20AM

    by RandomFactor (3682) Subscriber Badge on Saturday December 31 2016, @04:20AM (#447749) Journal

    TFA disagrees, as well as innumerable places on the interwebs.

    One example: http://www.historyofvaccines.org/content/articles/top-20-questions-about-vaccination [historyofvaccines.org]

    1. How do vaccines work? Do they work against viruses and bacteria?

    Vaccines work to prime your immune system against future “attacks” by a particular disease. There are vaccines against both viral and bacterial pathogens, or disease-causing agents.

    Not my area so enlighten please. Is there a technical term being abused, language drift?

    --
    В «Правде» нет известий, в «Известиях» нет правды
    • (Score: 0) by Anonymous Coward on Saturday December 31 2016, @05:08AM

      by Anonymous Coward on Saturday December 31 2016, @05:08AM (#447761)

      Vaccine is dead or weakened virus injected so that the immune system is primed with the specific antibody against the virus. This mechanism doesn't work against bacterial infection.

      • (Score: 0) by Anonymous Coward on Saturday December 31 2016, @07:16AM

        by Anonymous Coward on Saturday December 31 2016, @07:16AM (#447788)

        nope.

      • (Score: 0) by Anonymous Coward on Saturday December 31 2016, @07:38AM

        by Anonymous Coward on Saturday December 31 2016, @07:38AM (#447791)

        There are vaccines for TB, anthrax, typhus, and bacterial meningitis. I'm not sure about eukaryotic parasites, but there's certainly people working on malaria and sleeping sickness.

      • (Score: 0) by Anonymous Coward on Saturday December 31 2016, @12:26PM

        by Anonymous Coward on Saturday December 31 2016, @12:26PM (#447832)

        What vaccination does is to present a characteristic (but harmless) fragment of surface structure of the "bad guy" to train the immune system, so there is no fundamental reason why this would not work for (or rather against) bacteria - indeed there are even experimental cancer therapies based on this concept. The crucial part is to find something that is characteristic for at least some strains of the pathogen, does not change easily and is sufficiently different from what our own body cells display.

  • (Score: 0) by Anonymous Coward on Saturday December 31 2016, @08:47PM

    by Anonymous Coward on Saturday December 31 2016, @08:47PM (#447941)

    For all I know you're trolling, but vaccines can be made to protect against viruses, bacteria, and even some larger molecules. If you're not simply trolling, you may also be getting tripped up by mixing up vaccines and antibiotics in your head; antibiotics are only effective against bacteria and not viruses...