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posted by cmn32480 on Friday January 06 2017, @04:54PM   Printer-friendly
from the maybe-it-is-a-dinopeptic-germ dept.

In a population-based study from Scotland, use of commonly-prescribed acid suppression medications such as proton pump inhibitors (PPIs) was linked with an increased risk of intestinal infections with C. difficile and Campylobacter bacteria, which can cause considerable illness.

Compared with individuals in the community who did not take acid suppression medications, those who did had 1.7-times and 3.7-times increased risks of C. difficile and Campylobacter, respectively. Among hospitalized patients, those using the medications had 1.4-times and 4.5-times increased risks, respectively.

Although acid suppression therapy is often considered relatively free from side effects, the findings suggest that there are significant adverse gastrointestinal consequences of their use. "Users of these medications should be particularly vigilant about food hygiene as the removal of stomach acid makes them more easily infected with agents such as Campylobacter, which is commonly found on poultry," said Prof. Thomas MacDonald, senior author of the British Journal of Clinical Pharmacology study.

DOI: 10.1111/bcp.13205

Maybe they should cut back on haggis and chips instead.


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  • (Score: 4, Insightful) by ikanreed on Friday January 06 2017, @06:50PM

    by ikanreed (3164) Subscriber Badge on Friday January 06 2017, @06:50PM (#450349) Journal

    You know, I wasn't expecting so much outrage over reading a scientific study and pointing out major issues. I was expecting someone to point out that maybe I looked at the wrong table, and have an analysis of how many different tests it takes before you get to accidental p-hacking.

    As to who cares? Obviously I care. I like people to get treatment that works. That matters to me on a moral level. Yes, even for non-fatal conditions. Undue suffering is bad.
    I also care because I like analyzing research papers. I find it fun and interesting to do. And I like sharing my results.
    Other people might also care, because hell, maybe others reading this thread also care about using treatments that work. I don't know. I certainly don't see the harm in sharing.

    Starting Score:    1  point
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  • (Score: -1, Troll) by Anonymous Coward on Friday January 06 2017, @07:06PM

    by Anonymous Coward on Friday January 06 2017, @07:06PM (#450354)

    No wonder you are all worked up.
    You've made your objection into a part of your identity and the people telling you its misguided are now perceived as attacking your identity.

    • (Score: 3, Funny) by ikanreed on Friday January 06 2017, @07:40PM

      by ikanreed (3164) Subscriber Badge on Friday January 06 2017, @07:40PM (#450369) Journal

      "Sure you explained your motivations for bringing it up in fine detail, but I can still make up new ones for you that make you wrong"

      Congratulations, the fictitious version of me whose identity is tied up in this is utterly destroyed. You defeated that dragon, and saved the princess, you can go home and continue being totally wrong in peace.

      • (Score: 0) by Anonymous Coward on Friday January 06 2017, @08:58PM

        by Anonymous Coward on Friday January 06 2017, @08:58PM (#450422)

        Yes, if there is one thing you've demonstrated with all of your hyperbole its that you are a creature of pure logic and no ego.

  • (Score: 0) by Anonymous Coward on Friday January 06 2017, @11:35PM

    by Anonymous Coward on Friday January 06 2017, @11:35PM (#450503)

    Where did you find that n=7? Can you quote the line? I see this:

    A population-based, propensity-score matched cohort study using a record-linkage database in Tayside, Scotland. The study consisted of 188,323 exposed to ASMs [proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RA)] and 376,646 controls (a propensity-score matched cohort from the rest of population who were not exposed to ASMs) between 1999 and 2013.

    http://onlinelibrary.wiley.com/doi/10.1111/bcp.13205/pdf [wiley.com]

    Also, most people rightly ignore what gets produced by medical researchers. That community has failed to control the quality of what it produces to such an epic extent it is literally unbelievable to anyone who thinks too much about the consequences. So I am not surprised no one else cared about what it said in the paper.

    • (Score: 2) by ikanreed on Friday January 06 2017, @11:57PM

      by ikanreed (3164) Subscriber Badge on Friday January 06 2017, @11:57PM (#450509) Journal

      This was the one linked in the G^nP's comment [asu.edu] suggesting vinegar could be used as an alternative treatment.

      I wasn't talking about the paper in the summary.

      • (Score: 0) by Anonymous Coward on Saturday January 07 2017, @08:14AM

        by Anonymous Coward on Saturday January 07 2017, @08:14AM (#450654)

        Thanks