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posted by Fnord666 on Tuesday March 07 2017, @09:47AM   Printer-friendly
from the gene,jean dept.

A definitive cause for autism spectrum disorders (ASD) has remained elusive, although the best picture so far seems to be one of a mix of genetic and environmental factors. This suggests that any genes involved with the condition by necessity are being passed on from generation to generation. A new study now suggests that these genes are being positively selected for.

The study, published in PLOS Genetics[open,DOI:10.1371/journal.pgen.1006618][DX], looked at the prevalence of alleles, or gene variants, commonly associated with an increased risk of ASD. The researchers discovered that these variants were found in much larger numbers than would be expected by chance, and they suggest that this may be because they are also linked to other genes implicated in cognitive ability.

The authors write that this positive selection between the genes thought to contribute to autism and those that might promote intelligence may explain why autism is such a prevalent condition, especially when it seems like it would have been selected against during human evolution.

http://www.iflscience.com/health-and-medicine/gene-variants-linked-to-autism-may-have-been-positively-selected-for/


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  • (Score: 0) by Anonymous Coward on Tuesday March 07 2017, @12:36PM (5 children)

    by Anonymous Coward on Tuesday March 07 2017, @12:36PM (#475977)

    The researchers discovered that these variants were found in much larger numbers than would be expected by chance, and they suggest that this may be because they are also linked to other genes implicated in cognitive ability.

    A deficits in social communication and social interaction is conducive to a highly probable "reproductive dead end".

  • (Score: 0) by Anonymous Coward on Tuesday March 07 2017, @01:48PM (1 child)

    by Anonymous Coward on Tuesday March 07 2017, @01:48PM (#475996)

    Incorrect.

    A sufficiently high population of "antisocial" humans could simply interbreed among themselves, as they do not see this as a negative selector.

    And for the record: a lot of what normies/ungifted people consider social, isn't.

    • (Score: 0) by Anonymous Coward on Tuesday March 07 2017, @08:20PM

      by Anonymous Coward on Tuesday March 07 2017, @08:20PM (#476163)

      Agreed ^

      Simply being around other people does not automatically make something a truly social activity. Also, a lot of "actual" social activity is simply superficial bullshit, circle-jerking into a sense of comfort that gives us some security in this insecure world.

  • (Score: 2, Insightful) by Anonymous Coward on Tuesday March 07 2017, @02:05PM

    by Anonymous Coward on Tuesday March 07 2017, @02:05PM (#476005)

    The researchers are saying that genes associated with autism were positively selected for. In other words, these genes are somehow beneficial for survival and reproduction, otherwise there would be mostly negative selection pressure. This is in direct contrast to your "reproductive dead end" hypothesis. Apparently whatever positive selection effect these genes have is stronger than the negative selection effects of autism disorders.

    Now why would genes that tend to cause or increase chances for autism be beneficial to survival? The theory here goes that these genes have other effects beside the possibility for autism disorders, namely promoting intelligence. It could be the case that autism spectrum disorders are simply a side-effect/cost of higher cognitive function. In other words, the prevalence of autism in individuals could be strongly related to our intelligence as a species.

    Also note that autism is a spectrum, not a binary condition. There are many people high on the spectrum, who have difficulties socializing or other issues, but who otherwise live perfectly normal lives and will never have an ASD diagnosis. It only becomes a problem (and is diagnosed as a disorder) when the autism traits are so extreme that they impede an individual's everyday life or functioning in society. I believe right now we are only seeing the tip of the iceberg, the extreme cases, but we are slowly starting to see more of it as we gain understanding of this spectrum.

  • (Score: 0) by Anonymous Coward on Tuesday March 07 2017, @07:09PM

    by Anonymous Coward on Tuesday March 07 2017, @07:09PM (#476133)

    A deficits in social communication and social interaction is conducive to a highly probable "reproductive dead end".

    Not necessarily. Maybe anti-social people have learned to live in the hills. Whenever a big war happens, they survive because the invaders are unlikely to go into the spooky hills to root out a small number of people.

  • (Score: 2) by ese002 on Tuesday March 07 2017, @07:52PM

    by ese002 (5306) on Tuesday March 07 2017, @07:52PM (#476154)

    A deficits in social communication and social interaction is conducive to a highly probable "reproductive dead end".

    Only when extreme. The research suggests that genes that increase risk of autism also increase neural capacity. So, as long you don't get full hammer of autism, you get higher intelligence. That is a reproductive advantage.

    The classic example of this effect is sickle cell anaemia> [sciencedaily.com]. Two copies of the gene results in a deadly genetic disease. But inheriting the sickle cell gene from only one parent improves resistance to malaria. Thus, the gene persists in areas with high incidence of malaria.