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posted by on Thursday May 04 2017, @05:10AM   Printer-friendly
from the Cancerous-cancer-causes-cancer dept.

MedicalXpress.Com is reporting on new research into how cancer metastasizes. In a paper published on 18 April 2017 in Cell Reports, researchers at The Scripps Research Institute (TSRI) identified pathways used by cancer to spread beyond their primary tumors.

From the MedicalXpress article:

Even in remission, cancer looms. Former cancer patients and their doctors are always on alert for metastatic tumors. Now scientists at The Scripps Research Institute (TSRI) have discovered why some cancers may reoccur after years in remission.

The findings, published recently in the journal Cell Reports, show that invasive tumors can begin sending out tumor cells far earlier than previously thought. These escaping cells—which can enter the bloodstream before the primary tumor is detected—may seed secondary tumors that don't show up for years.

Importantly, the scientists demonstrated that the escaping tumor cells reach the bloodstream by entering blood vessels deep within the dense tumor core, upending the long-held belief that metastatic cells come from a tumor's invasive borders.

"The actual process of cancer cell dissemination via hematogenous routes is a relatively under-studied process, but we finally have an answer as to where it takes place," said TSRI Assistant Professor Elena Deryugina, who led the study in a long-term collaboration with TSRI Staff Scientist William Kiosses.

Journal Reference: Intratumoral Cancer Cell Intravasation Can Occur Independent of Invasion into the Adjacent Stroma


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  • (Score: 1) by Zipf on Thursday May 04 2017, @07:11PM (2 children)

    by Zipf (2400) on Thursday May 04 2017, @07:11PM (#504483)

    I know that sucralose can fake-out gut bacteria and cause them to die.

    Isn't cancer supposed to be sugar-hungry?

    IV sucralose - a non-caloric sweetener -- and watch the cancer eat it up.
    I suspect that if it works, starved tissue breaks off and causes distant mets.

    I would personally fund (well, within reason) a rat study in this.

  • (Score: 0) by Anonymous Coward on Thursday May 04 2017, @08:34PM (1 child)

    by Anonymous Coward on Thursday May 04 2017, @08:34PM (#504515)

    Its like $1.50 - $3.00 per day per cage (2 rats per cage) just to house them. So about $20-$45 per month per rat.

    • (Score: 1) by Zipf on Friday May 05 2017, @12:55PM

      by Zipf (2400) on Friday May 05 2017, @12:55PM (#504811)

      If you are serious, pm me.