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posted by n1 on Tuesday June 13 2017, @01:46PM   Printer-friendly
from the also-works-on-children dept.

A chemical currently being used to ward off mosquitoes carrying the Zika virus and a commonly used insecticide that was threatened with a ban in the United States have been associated with reduced motor function in Chinese infants, a University of Michigan study found.

Researchers at the U-M School of Public Health and U-M Center for Human Growth and Development tested children in China and found exposure to the chemical naled via their mothers during pregnancy was associated with 3-4 percent lower fine motor skills scores at age 9 months for those in the top 25 percent of naled exposure, compared to those in the lowest 25 percent of exposure. Infants exposed to chlorpyrifos scored 2-7 percent lower on a range of key gross and fine motor skills.

Girls appeared to be more sensitive to the negative effects of the chemicals than boys.

Naled is one of the chemicals being used in several U.S. states to combat the mosquito that transmits Zika. Chlorpyrifos, around since the 1960s, is used on vegetables, fruit and other crops to control pests.

Both are insecticides called organophosphates, a class of chemicals that includes nerve agents like sarin gas. They inhibit an enzyme involved in the nerve signaling process, paralyzing insects and triggering respiratory failure. However, they may adversely impact health through other mechanisms at lower exposure levels that are commonly encountered in the environment.

In the children studied, naled affected fine motor skills or the small movements of hands, fingers, face, mouth and feet. Chlorpyrifos was associated with lower scores for both gross (large movements of arms and legs) and fine motor skills.

-- submitted from IRC


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  • (Score: 2) by JoeMerchant on Wednesday June 14 2017, @12:00PM

    by JoeMerchant (3937) on Wednesday June 14 2017, @12:00PM (#525379)

    I agree about the "null hypothesis hole" in the published literature, although meta-analysis papers (such as the one I linked) do seem to frequently take pot-shots at the body of work (deserved? maybe) and attempt to nullify results with criticism when there is clear unidirectional bias in the papers being studied i.e. calls for standardized methods, increased sample sizes, etc. To me it often reads like: "I tried to analyze these 150 publications for my PhD, but it was hard because everybody used their own methods and I can't figure out how to lump the results together in a clean, defensible package."

    The XKCD882 phenomenon is well understood and exploited by industry (pharmaceutical I know from personal dealings, I'm sure pesticides are in on the game also) wherein they launch a number of "trade secret protected" clinical trials and/or studies and then shut down the ones that don't appear to be generating the desired results - then, if they are lucky enough, they get one or more "statistically significant" results which back up their billion dollar product, at least long enough for it to make back the development costs.

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