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from the just-another-reason-to-not-be-obese dept.
Submitted via IRC for TheMightyBuzzard
Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells, making them more aggressive as a result. Scientists from Helmholtz Zentrum München, Technical University of Munich (TUM), and Heidelberg University Hospital report on this in 'Cell Metabolism'. The team has already been able to halt this mechanism with an antibody treatment.
The number of people with obesity is increasing rapidly worldwide. The German Cancer Research Center (DKFZ) recently reported that according to the WHO the number of children and adolescents with obesity increased tenfold between 1975 and 2016. Severe overweight can lead to various health impairments. Besides inducing cardiovascular diseases, obesity for example also promotes the development of cancer and metastases.
The current study elucidates an as yet unknown mechanism making breast cancer more aggressive. The enzyme ACC1* plays a central role in this process," said Dr. Mauricio Berriel Diaz, deputy director of the Institute for Diabetes and Cancer (IDC) at Helmholtz Zentrum München. He led the study together with Stephan Herzig, director of the IDC and professor for Molecular Metabolic Control at TUM and Heidelberg University Hospital. "ACC1 is a key component of fatty acid synthesis," said Berriel Diaz. "However, its function is impaired by the cytokines leptin and TGF-β." The levels of these cytokines are increased particularly in the blood of severely overweight subjects.
(Score: 4, Informative) by Snotnose on Tuesday October 24 2017, @11:33PM (5 children)
If I've learned anything from decades of Civilization, the more food that is available the faster your colony will grow. Fat people tend to have bigger boobs (I pity the fat chick with no titties), hence the breast cancer cells can feast and grow fat faster.
/ This is probably the most politically incorrect post I've made in 30 years
// harking back to the days of alt.tasteless
/// squicking jokes were the thing back then
When the dust settled America realized it was saved by a porn star.
(Score: 2) by Snotnose on Wednesday October 25 2017, @12:43AM (3 children)
I never ever expected this to be rated insightful.....
When the dust settled America realized it was saved by a porn star.
(Score: 2) by fishybell on Wednesday October 25 2017, @01:24AM
Don't worry, I down-voted it.
(Score: 2) by Snotnose on Thursday October 26 2017, @12:24AM (1 child)
Nor informative. It was a tasteless joke FFS, WTF is with you moderators.
When the dust settled America realized it was saved by a porn star.
(Score: 2) by Snotnose on Thursday October 26 2017, @12:27AM
To be clear, I expect a +3 funny on my post. +5 would be great. But insightful? Informative? It's bullshit. Comparing a computer game to breast cancer is about as stupid as stupid gets.
When the dust settled America realized it was saved by a porn star.
(Score: 0) by Anonymous Coward on Wednesday October 25 2017, @12:20PM
Adipocytes are not a substantial contributer to the breast tumor microenvironment. While there are some cases of cancer cells "eating" (entosis) other cancer cells, adipocytes do not play a role in this.
https://en.wikipedia.org/wiki/Entosis [wikipedia.org]