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from the just-another-reason-to-not-be-obese dept.
Submitted via IRC for TheMightyBuzzard
Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells, making them more aggressive as a result. Scientists from Helmholtz Zentrum München, Technical University of Munich (TUM), and Heidelberg University Hospital report on this in 'Cell Metabolism'. The team has already been able to halt this mechanism with an antibody treatment.
The number of people with obesity is increasing rapidly worldwide. The German Cancer Research Center (DKFZ) recently reported that according to the WHO the number of children and adolescents with obesity increased tenfold between 1975 and 2016. Severe overweight can lead to various health impairments. Besides inducing cardiovascular diseases, obesity for example also promotes the development of cancer and metastases.
The current study elucidates an as yet unknown mechanism making breast cancer more aggressive. The enzyme ACC1* plays a central role in this process," said Dr. Mauricio Berriel Diaz, deputy director of the Institute for Diabetes and Cancer (IDC) at Helmholtz Zentrum München. He led the study together with Stephan Herzig, director of the IDC and professor for Molecular Metabolic Control at TUM and Heidelberg University Hospital. "ACC1 is a key component of fatty acid synthesis," said Berriel Diaz. "However, its function is impaired by the cytokines leptin and TGF-β." The levels of these cytokines are increased particularly in the blood of severely overweight subjects.
(Score: 0) by Anonymous Coward on Wednesday October 25 2017, @02:00AM
I'd say it's not quite as acute as nicotine withdrawal, but it's much more persistent, if that makes sense.
To compound that, an unhealthy body is in constantly calorie conservation mode. Cortisol does that I believe. Cannabis can counteract that.
However, a new diet does take some getting used to. I say diet, but I don't mean fad diets. I mean diet, as in what food habits can I reprogram to serve me well for the rest of my life? I hit a wall when I was losing weight recently. I started a food journal and meticulously noted how many calories what I ate had. Then I reduced the maximum number of calories I could eat in a day: ice cream, candy, or more healthy options like rice or steak, it was totally up to me how I wanted to allocate my calorie budget. I started losing weight again.
In fact, the odd thing is that now that I'm around my ideal weight, I've had some trouble raising my calorie budget. That's how used to only having 800 kcal per day to allocate I was. I just never, ever want to be fat again. Therefore, I'm finding food habits that will serve me well for the rest of my life.
I was feeling depressed today, so I had a small box of sour gummy worms. Heh, it didn't make me feel any better, but I had unallocated calories in my budget, so I feel no guilt about it. Tomorrow I'll get a new budget, and today's indulgences needn't affect tomorrow's budget.