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from the just-another-reason-to-not-be-obese dept.
Submitted via IRC for TheMightyBuzzard
Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells, making them more aggressive as a result. Scientists from Helmholtz Zentrum München, Technical University of Munich (TUM), and Heidelberg University Hospital report on this in 'Cell Metabolism'. The team has already been able to halt this mechanism with an antibody treatment.
The number of people with obesity is increasing rapidly worldwide. The German Cancer Research Center (DKFZ) recently reported that according to the WHO the number of children and adolescents with obesity increased tenfold between 1975 and 2016. Severe overweight can lead to various health impairments. Besides inducing cardiovascular diseases, obesity for example also promotes the development of cancer and metastases.
The current study elucidates an as yet unknown mechanism making breast cancer more aggressive. The enzyme ACC1* plays a central role in this process," said Dr. Mauricio Berriel Diaz, deputy director of the Institute for Diabetes and Cancer (IDC) at Helmholtz Zentrum München. He led the study together with Stephan Herzig, director of the IDC and professor for Molecular Metabolic Control at TUM and Heidelberg University Hospital. "ACC1 is a key component of fatty acid synthesis," said Berriel Diaz. "However, its function is impaired by the cytokines leptin and TGF-β." The levels of these cytokines are increased particularly in the blood of severely overweight subjects.
(Score: 2) by The Mighty Buzzard on Wednesday October 25 2017, @02:20AM (2 children)
Sometimes. Most of the time you're just a fatass who needs to do more of the hard, physical work the human body has evolved to do. It's going to be a long damn time before desk jobs and sitting on your ass watching television are sufficient for a healthy body.
My rights don't end where your fear begins.
(Score: 1) by dwilson on Wednesday October 25 2017, @04:58AM (1 child)
From what I've seen personally, it may not even require a lot of hard, physical work. Energy in, energy out. If you can't change one, change the other.
Nine years ago I was fairly active in one of the local martial arts clubs. I'd been there for several years at that point. One day, a stranger I'd never seen showed up for the class. Most of the other regulars who'd been there longer than I recognized him as someone who used to be a regular and had disappeared for a long while. The instructor greeted everyone as they showed up, before the lessons started. I'll never forget the exchange I overheard (paraphrasing here, it was years ago and I don't recall the exact wording):
"Phil! Jesus, you're half the man you used to be. How the hell did you lose all that weight? You've never looked this good!"
"Honestly? I just started eating less."
"...that's it? You weighed three hundred and fifty pounds dude. Seriously, what happened?"
"Once I accepted that I'd feel hungry whenever I was awake, things got a lot easier."
That may not have been all there was to it, but it's stuck with me. As I approach middle age, whenever I notice my weight climbing, I spend a few weeks (sometimes months) re-learning to enjoy the feeling of being hungry, and things drop back in to place. It's not that you can't eat, just don't eat as much as you want. Don't eat until you feel full.
I'm still fairly active too, though. YMMV.
...milage. Heh, I'm hilarious.
- D
(Score: 2) by The Mighty Buzzard on Wednesday October 25 2017, @10:24AM
Yup, I'm in need of reteaching myself that lesson too lately. The Roomie getting a riding mower has done me no favors this mowing season.
My rights don't end where your fear begins.