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The world's most famous sheep didn't experience accelerated aging due to cloning, University of Nottingham researchers report:
In the scientific version of her obituary, Dolly the Sheep was reported to have suffered from severe arthritis in her knees. The finding and Dolly's early death from an infection led many researchers to think that cloning might cause animals to age prematurely.
But new X-rays of Dolly's skeleton and those of other cloned sheep and Dolly's naturally conceived daughter Bonnie indicate that the world's first cloned mammal had the joints of normal sheep of her age. Just like other sheep, Dolly had a little bit of arthritis in her hips, knees and elbows [open, DOI: 10.1038/s41598-017-15902-8] [DX], developmental biologist Kevin Sinclair of the University of Nottingham in England and colleagues report November 23 in Scientific Reports.
The researchers decided to reexamine Dolly's remains after finding that her cloned "sisters" have aged normally and didn't have massive arthritis (SN: 8/20/16, p. 6). No formal records of Dolly's original arthritis exams were kept, so Sinclair and colleagues got Dolly and Bonnie's skeletons and those of two other cloned sheep, Megan and Morag, from the National Museums Scotland in Edinburgh. Megan and Bonnie were both older than Dolly at the time of their deaths and had more bone damage than Dolly did. Morag died younger and had less damage.
How many times has the story of Dolly's death at the ripe age of 6 (with a supposed genetic starting age of 6 due to shorter telomeres) been used as a bludgeon against cloning?
Previously: Dolly at 20: The Inside Story on the World's Most Famous Sheep
Cloned Sheep Age Normally
(Score: 1, Informative) by Anonymous Coward on Friday November 24 2017, @02:05PM (4 children)
Except telomeres regenerate...
https://www.newscientist.com/article/1989324-healthy-living-can-turn-our-cells-clock-back/ [newscientist.com]
So yeah, the premature news about "telomeres" for last decade is just that, news from people that don't know what they are talking about giving the impression that things are set in stone. Remember few decades back when everyone believed that brains don't create new neurons after child's brain matures? Yeah, like that....
Aging has more to do with complex systems failing than anything else. It's death by thousand cuts, not because of any individual thing.
(Score: 3, Informative) by takyon on Friday November 24 2017, @02:17PM
https://en.wikipedia.org/wiki/Strategies_for_Engineered_Negligible_Senescence [wikipedia.org]
[SIG] 10/28/2017: Soylent Upgrade v14 [soylentnews.org]
(Score: 2) by frojack on Friday November 24 2017, @07:55PM (2 children)
When you see shit like that in a study, that should be your clue to run away from that study like your hair was on fire.
No, you are mistaken. I've always had this sig.
(Score: 0) by Anonymous Coward on Friday November 24 2017, @11:05PM
...and have shorter telomeres.
the more strictly the 10 men stuck to the healthy regime, the longer their telomeres became
Another aspect to be considered is that your extra years will all have been used up attending meetings, "meditating" and "eating lawn clippings" (as Dean Edell MD would call that).
-- OriginalOwner_ [soylentnews.org]
(Score: 1) by khallow on Saturday November 25 2017, @01:48AM