One of the key steps in developing new drugs is determining the atomic structure of its biologically active substances. This generally involves performing X-ray analyses of single crystal structures to determine the ingredient's detailed three-dimensional set-up. However, growing suitable single crystals is often a complex and time-consuming process.
A research group headed up by Bernhard Spingler, professor at the Department of Chemistry of the University of Zurich, has now modified a method that had previously been used exclusively for the crystallization of proteins, and successfully applied it to organic salts. The team was able to determine the crystal structures of several organic salts with significantly less time and effort. "As organic salts make up about 40 percent of all active pharmaceutical ingredients, this new method can greatly speed up the development of drugs," says Spingler.
[...] The breakthrough in developing the novel method was achieved by Philipp Nievergelt, a trainee who had spent 10 months in Bernhard Spingler's lab after graduating from Gymnasium. The successful junior researcher is listed as first author of the study and is now four semesters into his business chemistry studies at UZH. "The traineeship got me excited about lab work and encouraged me to continue doing research," explains Nievergelt.
(Score: 0) by Anonymous Coward on Tuesday March 27 2018, @10:32PM (2 children)
We have no problems with finding new active molecule and no shortage of chemical engineers to figure how to mass produce them. We have a problem with finding new drugs that work better than the one we currently have. I do not see how a new cool synth tech address that
(Score: 2) by c0lo on Tuesday March 27 2018, @11:27PM (1 child)
Faster structure determination may lead to more already-known-as-working structure mapping.
A more comprehensive atlas of such structures may lead to seeing patterns emerge, hypotheses formulated, targeted research to confirm/falsify the hypotheses, etc... so that new effective compounds are searched and found into narrower fields. All in all, a faster pace of finding new compounds.
Or it may lead to nothing, but then you will know why this is a dead end, a valuable piece of information in itself.
https://www.youtube.com/watch?v=aoFiw2jMy-0 https://soylentnews.org/~MichaelDavidCrawford
(Score: 1, Interesting) by Anonymous Coward on Wednesday March 28 2018, @12:01AM
here http://blogs.sciencemag.org/pipeline/archives/2017/08/02/how-long-oh-lord-how-long [sciencemag.org]