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A disputed paper that raised questions about the safety of CRISPR has been retracted:
A scientific paper that purported to lay bare serious flaws in the gene-editing tool known as CRISPR and briefly tanked shares of genome-editing companies has been retracted by its publisher.
The paper [DOI: 10.1038/nmeth.4293] [DX], published last year in Nature Methods, claimed that CRISPR wreaked havoc on the genome, causing hundreds of unintended mutations in mice — and that the algorithms typically used to detect these changes were routinely missing them.
[...] Two months after publication of the paper, Nature Methods published an "an expression of concern" about the paper in July. The retraction notice, appended Friday, goes further, saying the authors did not use mice that had been bred in their own laboratory — so they could not know if any genetic mutations were the result of their intervention with CRISPR editing, or if it stemmed from variations in the mice's own genomes.
Nature Methods editorial discussing the retraction: CRISPR off-targets: a reassessment (open, DOI: 10.1038/nmeth.4664) (DX)
Previously: CRISPR Safer than Thought; Misleading Study Found Shared Mutations in Closely Related Mice
(Score: 0) by Anonymous Coward on Wednesday April 04 2018, @03:42PM (3 children)
This is done with genetic screening of fertilzed eggs, no need for crispr to do that. What it could be used for along those lines is efficiently changing the dominant genotype of cells that can be removed from an already formed body, processed, and replaced (ie blood cells).
(Score: 0) by Anonymous Coward on Wednesday April 04 2018, @03:51PM (1 child)
In the future, when you're ready to have kids, you'll just pop down to the local convenience store, walk into the "family planning" aisle, and pick up a box of "Genetic Corrective".
Then, you'll ejaculate into a bowl, mix it with the Genetic Corrective, stir, allow it to sit for 10 minutes, pour into a turkey baster, insert into partner (who may be another man with an artificial womb), and spray.
If there are anomalies to correct, they will be corrected.
(Score: 2) by GreatAuntAnesthesia on Wednesday April 04 2018, @04:14PM
I hope he's had some other modifications done along with the womb, otherwise that insertion could be very uncomfortable.
(Score: 0) by Anonymous Coward on Wednesday April 04 2018, @10:08PM
You ain't looking far enough. Soon we may have Coordinators. [wikia.com]