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Major mental illnesses such as schizophrenia, severe depression and bipolar disorder share a common genetic link. Studies of specific families with a history of these types of illnesses have revealed that affected family members share a mutation in the gene DISC1. While researchers have been able to study how DISC1 mutations alter the brain during development in animal models, it has been difficult to find the right tools to study changes in humans. However, advancements in engineering human stem cells are now allowing researchers to grow mini-organs in labs, and gene-editing tools can be used to insert specific mutations into these cells.
Researchers from Brigham and Women's Hospital are leveraging these new technologies to study the effects of DISC1 mutations in cerebral organoids -- "mini brains" -- cultured from human stem cells. Their results are published in Translational Psychiatry.
"Mini-brains can help us model brain development," said senior author Tracy Young-Pearse, PhD, head of the Young-Pearse Lab in the Ann Romney Center for Neurologic Diseases at BWH. "Compared to traditional methods that have allowed us to investigate human cells in culture in two-dimensions, these cultures let us investigate the three-dimensional structure and function of the cells as they are developing, giving us more information than we would get with a traditional cell culture."
(Score: 2) by JoeMerchant on Sunday April 22 2018, @04:17AM (5 children)
That is extreme, and I'm sure you know that there are pills for that (not that they solve everything, but...)
On the other hand, I know some highly functional ADHD people who live like that almost all the time, if you can carry on a conversation with them for 3 minutes without them getting 100% distracted by something entirely different that's an unusual event.
🌻🌻 [google.com]
(Score: 2) by MichaelDavidCrawford on Sunday April 22 2018, @06:23AM (2 children)
To quickly move from topic to topic is also regarded as a symptom of mania; that lead every Kuron and his brother to claim I was manic when I was just being creative.
Somewhere I found a page that argued for flight of ideas to be a completely normal behavior of creative people, but linking never satisfied my many Kuron friends.
Racing thoughts exhibit flight of ideas, but to think that way is very taxing because when I'm manic I think so FAST.
There are some good things about being hypomanic - "less manic" - but I avoid even hypomania because full-blown mania often follows. When I'm manic I'm like a bull in a china shop. A very charming, witty and friendly bull but still a self-driven engine of destruction.
Yes I Have No Bananas. [gofundme.com]
(Score: 2) by JoeMerchant on Sunday April 22 2018, @11:50AM (1 child)
Google is weak on the Kuron reference...?
🌻🌻 [google.com]
(Score: 2) by MichaelDavidCrawford on Sunday April 22 2018, @02:35PM
BEHOLD. [archive.org]
Us Kurons got the bad news that the server's entire data center got decommissioned without Lawrence Calvin "Rust" Foster III even knowing about it.
He gets a lot of email, see. And he very rarely actually checks it.
Rusty announced that he would publish a read-only archive. That there is still no such archive leads us all to believe that he didn't have any offsite backups.
Yes I Have No Bananas. [gofundme.com]
(Score: 2) by Freeman on Monday April 23 2018, @03:27PM (1 child)
I suspect the 3 minutes is quite an exaggeration as I'm a "highly functioning ADHD" person. Though, it's quite possible that the environment you're interacting with them in is highly distracting. A calm relaxing environment with few distractions greatly helps someone with ADHD. I've learned that Caffeine can be my friend too. Best effect with as little sugar as possible.
Joshua 1:9 "Be strong and of a good courage; be not afraid, neither be thou dismayed: for the Lord thy God is with thee"
(Score: 2) by JoeMerchant on Monday April 23 2018, @04:53PM
Yeah, standing outside is not the best place even for me - there's always a weed to pull, an ant to track back to their source, etc.
🌻🌻 [google.com]