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Culprit In Reducing Effectiveness Of Insulin Identified

posted by mrpg on Friday April 27 2018, @01:44AM   
from the macross dept.

Arthur T Knackerbracket has found the following story:

Scientists at Osaka University discovered that Stromal derived factor-1 (SDF-1) secreted from adipocytes reduced the effectiveness of insulin in adipocytes and decreased insulin-induced glucose uptake.

[...] Using microarray database analysis, this group of scientists identified SDF-1 as a factor to enhance expression in adipocytes in both fasting and obese states and found that SDF-1 reduced the effectiveness of insulin in adipocytes. In actuality, in SDF-1 knockout mice, insulin-induced glucose uptake increased (i.e., blood sugar levels decreased), and insulin efficacy improved (i.e., insulin sensitivity was enhanced). Their research results were published in Diabetes.

Based on the results of this study, it is expected that insulin sensitivity in adipocytes will increase by inactivating the SDF-1 signaling pathway, which will lead to treatment of obese type 2 diabetes.

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Original Submission

• SDF-1 SDF-1 (Score: 3, Funny) by Kell on Friday April 27 2018, @03:54AM (1 child)

  by Kell (292) on Friday April 27 2018, @03:54AM (#672468)

  Sounds more like it should be fighting Zentraedi instead of insulin.

  --
  Scientists ask questions. Engineers solve problems.

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• Re:SDF-1 (Score: 2) by shortscreen on Friday April 27 2018, @04:23AM

  by shortscreen (2252) on Friday April 27 2018, @04:23AM (#672485) Journal

  Zentraedi aren't obese, they're just big-boned.

  Parent