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Culprit In Reducing Effectiveness Of Insulin Identified

posted by mrpg on Friday April 27 2018, @01:44AM   Printer-friendly
from the macross dept.

Arthur T Knackerbracket has found the following story:

Scientists at Osaka University discovered that Stromal derived factor-1 (SDF-1) secreted from adipocytes reduced the effectiveness of insulin in adipocytes and decreased insulin-induced glucose uptake.

[...] Using microarray database analysis, this group of scientists identified SDF-1 as a factor to enhance expression in adipocytes in both fasting and obese states and found that SDF-1 reduced the effectiveness of insulin in adipocytes. In actuality, in SDF-1 knockout mice, insulin-induced glucose uptake increased (i.e., blood sugar levels decreased), and insulin efficacy improved (i.e., insulin sensitivity was enhanced). Their research results were published in Diabetes.

Based on the results of this study, it is expected that insulin sensitivity in adipocytes will increase by inactivating the SDF-1 signaling pathway, which will lead to treatment of obese type 2 diabetes.

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  • (Score: 0) by Anonymous Coward on Friday April 27 2018, @10:47PM

    by Anonymous Coward on Friday April 27 2018, @10:47PM (#672825)

    There's more profit in this than in prevention. Putting the fork down and backing away from the pork chops is about all it really takes to avoid this.

    I have zero sympathy for the obese. Diabetes is nature's way of telling you to stop eating everything in sight.