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posted by mrpg on Sunday April 29 2018, @01:51AM   Printer-friendly
from the there's-always-a-secondary-effect dept.

[...] The research team studied the medical records of 40,770 patients aged over 65 diagnosed with dementia, and compared them to the records of 283,933 people without dementia. More than 27 million prescriptions were analysed.

[...] They found that there was a greater incidence of dementia among patients prescribed greater quantities of anticholinergic antidepressants, and anticholinergic medication for bladder conditions and Parkinson's.

[...] "We studied patients with a new dementia diagnosis and looked at what anticholinergic medication they were prescribed between four and 20 years prior to being diagnosed.

"We found that people who had been diagnosed with dementia were up to 30 per cent more likely to have been prescribed specific classes of anticholinergic medications. And the association with dementia increases with greater exposure to these types of medication.

"What we don't know for sure is whether the medication is the cause. It could be that these medications are being prescribed for very early symptoms indicating the onset of dementia.

"But because our research shows that the link goes back up to 15 or 20 years before someone is eventually diagnosed with dementia, it suggests that reverse causation, or confounding with early dementia symptoms, probably isn't the case.


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  • (Score: 2) by crafoo on Sunday April 29 2018, @04:22AM (3 children)

    by crafoo (6639) on Sunday April 29 2018, @04:22AM (#673235)

    Was it there time?
    Should everyone be given a DMT dose instead of the vaccine?
    I say yes. But you're average McD's Burger says no.
    Who to believe?

    Starting Score:    1  point
    Karma-Bonus Modifier   +1  

    Total Score:   2  
  • (Score: 4, Informative) by takyon on Sunday April 29 2018, @04:40AM (2 children)

    by takyon (881) <reversethis-{gro ... s} {ta} {noykat}> on Sunday April 29 2018, @04:40AM (#673242) Journal

    A DMT trip lasts about 10 minutes [erowid.org], Mr. Crapoo. If you really want America to shit its collective pants, what you need is a DMT drip [vice.com].

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    • (Score: 0) by Anonymous Coward on Sunday April 29 2018, @11:00AM (1 child)

      by Anonymous Coward on Sunday April 29 2018, @11:00AM (#673341)

      nono, that is if you extract and smoke it.
      i
      f you consume the beverage (the original concoction, essentially), it lasts for hours. Too long, too intense for many people if it is strong, but chances are you may vomit some of that out. it lasts so long you better have nothing else planned, and hopefully someone else is going to attend to your physical needs. or that you thought ahead and know the dose and how it is likely to affect you (and have a bucket and snacks nearby... in case walking is difficult).

      but... the smoked dmt trip, even if for 10 minutes, will put you in a place you may still believe could not even be imagined had you not seen it, so if you got the money, go get some. it won't change politics, your love life, or make you successful, but it might be very profound.

      the iv drip is really a fantastic notion i'd want if I was terminally ill and in a hospice and already said by goodbyes and was waiting for the end. may as well go on a high note

      • (Score: 2) by takyon on Sunday April 29 2018, @03:11PM

        by takyon (881) <reversethis-{gro ... s} {ta} {noykat}> on Sunday April 29 2018, @03:11PM (#673409) Journal

        There are other chemicals in ayahuasca [wikipedia.org] that cause the experience to be different than straight DMT. Even if the big difference is extra nausea:

        https://thethirdwave.co/ayahuasca-vs-dmt/ [thethirdwave.co]

        If ayahuasca contains DMT, why does the ayahuasca experience last so much longer than smoking DMT?

        We believe the answer is due to the means of ingestion. When you drink an ayahuasca brew, all the DMT is absorbed through your stomach lining. This is a slower form of DMT ingestion, so the DMT molecules won’t reach your brain as quickly, and won’t all be absorbed through your stomach at the same time. When you smoke DMT, the molecules are absorbed straight into your bloodstream through your lungs, meaning all the DMT hits your brain at once, very quickly. This is why, despite DMT being present in ayahuasca, the experiences can be very different.

        [...] As mentioned above, ayahuasca also contains MAOIs, and sometimes a variety of other plants depending on the region in which it’s made.

        Although the main role of the MAOIs in ayahuasca is to allow you to absorb DMT, they have also been implicated in psychedelic effects [nih.gov] themselves. It’s also the MAOIs that are responsible for the ‘purge’ at the beginning of the ayahuasca experience.

        One study [peerj.com] suggests that one of the MAOIs in ayahuasca can stimulate the growth of new brain cells in the lab – meaning it’s possible that the substance stimulates the formation of new connections in the brain.

        It’s most likely, however, that the moderate psychedelic effects of the MAOIs in ayahuasca are overwhelmed by the intense effects of the DMT.

        If you take ayahuasca, it’s important to remember that MAOIs can be very toxic when combined with certain other drugs or foods. Here is a complete list [ayahuasca.com] of the substances and foods that should be avoided when you take ayahuasca.

        If ayahuasca use is characterized by gradual absorption of DMT, the DMT drip could be considered the "sustained intense" version.

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