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posted by mrpg on Saturday May 12 2018, @08:35AM   Printer-friendly
from the keep-reaching-for-the-cure dept.

The surprising failure last month of a large clinical trial of a promising cancer immunotherapy drug from the biotech company Incyte has quickly reverberated across the pharmaceutical industry. Three companies have canceled, suspended, or downsized 12 other phase III trials of the compound, epacadostat, or two similar drugs, together slated to enroll more than 5000 patients with a variety of advanced cancers.

The companies say they aren't dropping the potential drugs, designed to unleash the immune system on cancer cells by blocking an enzyme called indoleamine (2,3)-dioxygenase (IDO). But the retrenching suggests that the frenzy to combine novel drugs with the wildly successful immunotherapies known as checkpoint inhibitors is outpacing the science. The IDO strategy, says neuroimmunologist Michael Platten of the University of Heidelberg in Germany, "has been moved to randomized clinical trials too fast, and now we realize [the enzyme is] still a black box."


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  • (Score: 0) by Anonymous Coward on Saturday May 12 2018, @04:59PM

    by Anonymous Coward on Saturday May 12 2018, @04:59PM (#678871)

    ... using typewriters.