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posted by mrpg on Thursday August 02 2018, @07:11AM   Printer-friendly
from the no-comment dept.

Study links depression to low blood levels of acetyl-L-carnitine

Investigators at Stanford and elsewhere have shown, for the first time in humans, that low blood levels of acetyl-L-carnitine track with the severity and duration of depression.

People with depression have low blood levels of a substance called acetyl-L-carnitine, according to a Stanford University School of Medicine scientist and her collaborators in a multicenter study.

Naturally produced in the body, acetyl-L-carnitine is also widely available in drugstores, supermarkets and health food catalogs as a nutritional supplement. People with severe or treatment-resistant depression, or whose bouts of depression began earlier in life, have particularly low blood levels of the substance.

The findings, published online July 30 in the Proceedings of the National Academy of Sciences, build on extensive animal research. They mark the first rigorous indication that the link between acetyl-L-carnitine levels and depression may apply to people, too. And they point the way to a new class of antidepressants that could be freer of side effects and faster-acting than those in use today, and that may help patients for whom existing treatments don't work or have stopped working.

Acetylcarnitine.

Also at The Rockefeller University.

Acetyl-l-carnitine deficiency in patients with major depressive disorder (DOI: 10.1073/pnas.1801609115) (DX)


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  • (Score: 3, Interesting) by DannyB on Thursday August 02 2018, @01:40PM (2 children)

    by DannyB (5839) Subscriber Badge on Thursday August 02 2018, @01:40PM (#716201) Journal

    Bonus points if we can come up with a crazy interpretation of some verse in the bible that prophecies the discovery of acetyl-L-carnitine so that when da starts going crazy on Prednisone again he can jump straight to the conclusion of shape-shifting demons from the burning hells.

    You have this wrong. Prophecy for a drug, a cure would then contradict the shape-shifting demons explanation. It's like saying that a prophecy for the discovery of insulin -- which would then contradict the explanation that the seizures were due to demonic possession rather than diabetic or epileptic seizures treatable by drugs.

    committed to an insane asylum and strapped into an electric chair every day

    The current US Vice President (unless he has announced a change in his views) believes that such treatment works for turning gay people straight. So it should also work with depressed people and be the first line of treatment rather than drugs.

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  • (Score: 0) by Anonymous Coward on Thursday August 02 2018, @02:24PM (1 child)

    by Anonymous Coward on Thursday August 02 2018, @02:24PM (#716232)

    Citation please, for the statement on the current US Vice President.

    • (Score: 2) by DannyB on Thursday August 02 2018, @06:57PM

      by DannyB (5839) Subscriber Badge on Thursday August 02 2018, @06:57PM (#716393) Journal

      After some googling . . .

      I am able to find that a social media post from a few years ago makes this statement, and is false. So wherever I picked up that false meme shows how well such things can spread. I will stop using it.

      I can also find that Mike Pence uses vague language which can be argued that it does or does not support gay conversion therapy. Even without the electric shock therapy, the idea of involuntarily subjecting anyone, especially a minor, to gay conversion therapy should be repugnant to anyone. The fact that the VP doesn't clarify his ambiguous language seems telling.

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