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Found: A Destructive Mechanism That Blocks the Brain From Knowing When to Stop Eating

posted by mrpg on Thursday August 23 2018, @11:11AM   Printer-friendly
from the smoke-gets-in-your-brain dept.

"exec" writes:

Arthur T Knackerbracket has found the following story:

An international team of researchers has uncovered a destructive mechanism at the molecular level that causes a well-known phenomenon associated with obesity, called leptin resistance.

They found that mice fed a high-fat diet produce an enzyme named MMP-2 that clips receptors for the hormone leptin from the surface of neuronal cells in the hypothalamus. This blocks leptin from binding to its receptors. This in turn keeps the neurons from signaling that your stomach is full and you should stop eating.

This is the first time that a destructive molecular mechanism has been observed and described.

Scientists showed that when MMP-2 is blocked, leptin can still bind to the receptors and signal satiety. They hope that in the future, clinicians will be able to treat leptin resistance in humans by blocking MMP-2. They also have evidence that their findings have a broader scope.

-- submitted from IRC

Original Submission

 
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  • (Score: 2) by JoeMerchant on Thursday August 23 2018, @12:03PM (6 children)

    by JoeMerchant (3937) on Thursday August 23 2018, @12:03PM (#725165)

    The secret ingredient in Tostitos, the thing Lays potato chips was trying to achieve through brainwashing.

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  • (Score: 2) by RS3 on Thursday August 23 2018, @02:38PM (5 children)

    by RS3 (6367) on Thursday August 23 2018, @02:38PM (#725216)

    I'm a general skeptic, but there must be something to this because I _never_ crave any food that's just the raw simple food. I love peaches but I don't crave them like I now want some Doritos thanks to you. :->

    • (Score: 2) by Freeman on Thursday August 23 2018, @03:57PM (4 children)

      by Freeman (732) on Thursday August 23 2018, @03:57PM (#725249) Journal

      You must have never had a superbly delicious peach. A good peach right off the tree, is so good, it makes you sad that you can't have them that way all the time. It's been a long time, since I've found a standard peach from a grocery store that was much good. Sometimes the Organic peaches are really good, but even those are usually picked too soon.

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