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posted by mrpg on Thursday August 23 2018, @11:11AM   Printer-friendly
from the smoke-gets-in-your-brain dept.

Arthur T Knackerbracket has found the following story:

An international team of researchers has uncovered a destructive mechanism at the molecular level that causes a well-known phenomenon associated with obesity, called leptin resistance.

They found that mice fed a high-fat diet produce an enzyme named MMP-2 that clips receptors for the hormone leptin from the surface of neuronal cells in the hypothalamus. This blocks leptin from binding to its receptors. This in turn keeps the neurons from signaling that your stomach is full and you should stop eating.

This is the first time that a destructive molecular mechanism has been observed and described.

Scientists showed that when MMP-2 is blocked, leptin can still bind to the receptors and signal satiety. They hope that in the future, clinicians will be able to treat leptin resistance in humans by blocking MMP-2. They also have evidence that their findings have a broader scope.

-- submitted from IRC


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  • (Score: 1, Interesting) by Anonymous Coward on Thursday August 23 2018, @02:43PM (1 child)

    by Anonymous Coward on Thursday August 23 2018, @02:43PM (#725220)

    Low-carb, high-fat diets are medicinal alternatives to high-protein diets for diabetes patients who can't process proteins. They're a sub-optimal choice (barely 1/5 of the success rate) and they have a whole range of complications that need addressing with pills.

    Just eat meat and veggies to your fill. Even with light seasoning (trace oils for cooking and taste) you'd never be able to reach anywhere near the intake you get from carbs. e.g. a quarter pounder is 330cals so even with 70cals worth of lard and some veggies you can eat that stuff 4 times a day and never come anywhere near caloric intake regardless of sex or height...

    Basically, eat exactly the opposite of what fat women diet on and you'd go thin.

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  • (Score: 1, Interesting) by Anonymous Coward on Thursday August 23 2018, @05:23PM

    by Anonymous Coward on Thursday August 23 2018, @05:23PM (#725282)

    What pills? The only difficulty I've seen so far is getting enough electrolytes. Its weird to force yourself to eat just so you can get some salts... It really makes you realize how depleted the soil must be of magnesium, etc:
    https://www.sciencedirect.com/science/article/pii/S221451411500121X [sciencedirect.com]