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posted by chromas on Friday October 12 2018, @04:20AM   Printer-friendly
from the vax>x86 dept.

A small but increasing number of children in the United States are not getting some or all of their recommended vaccinations. The percentage of children under 2 years old who haven't received any vaccinations has quadrupled in the last 17 years, according to federal health data released Thursday.

Overall, immunization rates remain high and haven't changed much at the national level. But a pair of reports from the Centers for Disease Control and Prevention about immunizations for preschoolers and kindergartners highlights a growing concern among health officials and clinicians about children who aren't getting the necessary protection against vaccine-preventable diseases, such as measles, whooping cough and other pediatric infectious diseases.

The vast majority of parents across the country vaccinate their children and follow recommended schedules for this basic preventive practice. But the recent upswing in vaccine skepticism and outright refusal to vaccinate has spawned communities of undervaccinated children who are more susceptible to disease and pose health risks to the broader public.

[...] The data underlying the latest reports do not explain the reason for the increase in unvaccinated children. In some cases, parents hesitate or refuse to immunize, officials and experts said. Insurance coverage and an urban-rural disparity are likely other reasons for the troubling rise.

Among children aged 19 months to 35 months in rural areas, about 2 percent received no vaccinations in 2017. That is double the number of unvaccinated children living in urban areas.

https://www.washingtonpost.com/national/health-science/percentage-of-young-us-children-who-dont-receive-any-vaccines-has-quadrupled-since-2001/2018/10/11/4a9cca98-cd0d-11e8-920f-dd52e1ae4570_story.html?utm_term=.3db2620fea5d


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  • (Score: 2, Informative) by Anonymous Coward on Friday October 12 2018, @04:06PM (5 children)

    by Anonymous Coward on Friday October 12 2018, @04:06PM (#747951)

    I've seen what the MMR has done to some kids

    I doubt that you've observed the MMR vaccine do anything. Just because something happened after something else, doesn't mean that the first thing caused the second. This is called the post hoc fallacy.

    The people that believe a MMR vaccine autism link were duped by a fraudulent study.
    People who believe that preservatives in vaccines cause autism are ignorant of the data that directly contradicts it.
    People who believe that "too many, too soon" and believe that combination vaccines are harmful are ignorant of the mechanisms of immunological memory.

    https://en.wikipedia.org/wiki/Post_hoc_ergo_propter_hoc [wikipedia.org]
    https://en.wikipedia.org/wiki/MMR_vaccine_controversy#1998_The_Lancet_paper [wikipedia.org]
    https://en.wikipedia.org/wiki/Thiomersal_controversy#Scientific_evaluation [wikipedia.org]
    https://en.wikipedia.org/wiki/Polyclonal_B_cell_response [wikipedia.org]

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  • (Score: 0) by Anonymous Coward on Friday October 12 2018, @04:34PM (2 children)

    by Anonymous Coward on Friday October 12 2018, @04:34PM (#747958)

    Just because something happened after something else, doesn't mean that the first thing caused the second. This is called the post hoc fallacy.

    Exactly. At the same time the measles vaccine was introduced there was also:

    1) A reduction in people purposefully spreading the disease (ie, measles parties)[1]
    2) The introduction of (unreliable)[2] blood tests to "confirm" the diagnoses based on symptoms alone[3, 4, 5, 6]
    3) The biasing of doctors to not diagnose measles if told the patient is vaccinated.[5]

    So how much did each factor contribute to the drop in measles diagnoses?

    Refs:

    “Before the introduction of measles vaccines, measles virus infected 95%–98% of children by age 18 years [1–4], and measles was considered an inevitable rite of passage. Exposure was often actively sought for children in early school years because of the greater severity of measles in adults.”

    [1] http://jid.oxfordjournals.org/content/189/Supplement_1/S4.full [oxfordjournals.org]

    Our data demonstrate that regression analysis shows only limited correlation between NT results and the ELISA values. This is in agreement with other reports [4]. Similar limitations in the correlation were also reported for other viruses like Cytomegalovirus (CMV) [10]. In case of the gamma globulin samples, the low correlation might reflect the wider spectrum and heterogeneity of the involved or measured measles antibodies.

    [2] http://www.ncbi.nlm.nih.gov/pubmed/17308917 [nih.gov]

    Indeed, an average of only 100 cases of measles are confirmed annually [32], despite the fact that >20,000 tests are conducted [28], directly suggesting the low predictive value of clinical suspicion alone.

    [3] Walter A. Orenstein, Rafael Harpaz; Completeness of Measles Case Reporting: Review of Estimates for the United States, The Journal of Infectious Diseases, Volume 189, Issue Supplement_1, 1 May 2004, Pages S185–S190, https://doi.org/10.1086/378501 [doi.org]

    “A likely reason for this is that the case may have been misdiagnosed as a non-specific viral illness. Measles has become relatively uncommon in Singapore with two decades of widespread measles vaccination, and especially after the second dose policy was implemented in 1998. Many primary care doctors may not even see a single case of measles in a year. This makes diagnosis more difficult.”

    [4] http://www.ncbi.nlm.nih.gov/pubmed/17609829 [nih.gov]

    “This was not a blind study, since the investigators knew which children had received measles vaccine. It seems probable that the occurrence of so much ‘measles-like’ illness in the vaccinated children was a reflexion of the difficulty in making a firm diagnosis of measles in the African child at one visit.”

    [5] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134550/ [nih.gov]

    “As only approximately 7% of the clinically-diagnosed cases of measles reported locally turned out to be measles by laboratory testing, there is a need for laboratory confirmation of measles to avoid misidentification of cases and improve disease surveillance.(2)”

    [6] http://www.ncbi.nlm.nih.gov/pubmed/17609829 [nih.gov]

    • (Score: 0) by Anonymous Coward on Friday October 12 2018, @05:52PM (1 child)

      by Anonymous Coward on Friday October 12 2018, @05:52PM (#747983)

      Are you trying to argue that the measles vaccine doesn't work?

      1. Your link is broken, but I doubt that a reduction in "measles parties" for children would dramatically reduce the infection rate for the entire population especially considering that it is an airborne disease.

      Ref. 2: An ELISA doesn't measure the same thing as a NT. An ELISA measures antibody binding to target antigens while an NT measures the neutralizing capacity of antibodies. Not all antibodies neutralize and not all neutralizing antibodies are equal.

      Ref. 3,4,6: I don't really get your point. Do you mean that a symptoms-based diagnostic is better than a blood test because the blood test is producing thousands of supposed false negatives or that a symptoms-based diagnostic is unreliable because it's producing false negatives since the doctors aren't used to seeing measles anymore?

      Ref. 5: Are you saying that the lack of blinding in a small efficacy study (80% disease in unvaccinated vs 0% in vaccinated) from over 50 years ago proves the vaccine doesn't work?

      https://en.wikipedia.org/wiki/ELISA [wikipedia.org]
      https://en.wikipedia.org/wiki/Neutralizing_antibody [wikipedia.org]

      • (Score: 0) by Anonymous Coward on Friday October 12 2018, @06:52PM

        by Anonymous Coward on Friday October 12 2018, @06:52PM (#748003)

        Your link is broken

        Interesting...
        The Clinical Significance of Measles: A Review. Robert T. Perry and Neal A. Halsey. The Journal of Infectious Diseases 2004; 189(Suppl 1):S4–16. https://www.ncbi.nlm.nih.gov/pubmed/15106083 [nih.gov]
        pdf here: https://pdfs.semanticscholar.org/b7e0/c83a2232536a507ef061563000b59d97db66.pdf [semanticscholar.org]

        but I doubt that a reduction in "measles parties" for children would dramatically reduce the infection rate for the entire population especially considering that it is an airborne disease.

        Once someone gets (full blown) measles they are immune for the rest of their lives. Since everyone is a child at some point and 95% of children got measles, it was pretty much only children that got measles.

        Are you trying to argue that the measles vaccine doesn't work?

        No, I'm asking what was the relative contribution of each of those factors to the drop in measles diagnoses?

        An ELISA doesn't measure the same thing as a NT. An ELISA measures antibody binding to target antigens while an NT measures the neutralizing capacity of antibodies. Not all antibodies neutralize and not all neutralizing antibodies are equal.

        They have multiple blood tests for measles that don't correlate well with each other, so how are they considered reliable?

        Ref. 3,4,6: I don't really get your point.

        Before the vaccine, measles was diagnosed based solely on the symptoms. The vaccine was introduced at around the same time as the blood tests, and the clinical definition of measles was eventually changed to require a confirmatory blood test. The info in those citations shows that 90-99.5% of symptomatic measles cases are not confirmed as measles by the blood tests. Thus, it is possible that 90+% of what was called measles before vaccines and blood tests (~1965) was actually something else. Ie, in the worst case scenario the pre-1964 data here could be 10-200x too high: https://en.wikipedia.org/wiki/File:Measles_US_1944-2007_inset.png [wikipedia.org]

        Now the reality is much more messy since the blood tests were not adopted all at once. Some doctors would use it, others wouldnt, and it depended on the situation. Even by 1982, most people were not getting confirmatory tests:

        Serologic confirmation of diagnosis, while highly desirable, is rarely carried out in a large proportion of cases. In addition, the people that are tested probably do not represent a random subset of illnesses in the community but rather are selected on the basis of prior vaccination status, atypical clinical presentation, and/or ease of obtaining a convalescent serum specimen.

        http://www.ncbi.nlm.nih.gov/pubmed/6751071 [nih.gov]

        Here we can see the progression of the measles diagnostic criteria. First thing to note is they started the vaccination campaign without even agreeing on the definition of "measles" until 15 years later. Second is the the definition becomes more and more strict over time, eventually only "laboratory confirmed" cases are counted.

        1983:

        In April 1979, the Conference of State and Territorial Epidemiologists agreed to adopt a standard case definition of measles to permit more uniformity in their reporting of clinically confirmed measles cases.
        [...]
        A diagnosis should be considered confirmed in the presence of good clinical and/or epidemiologic evidence, even in the absence of confirmatory serology.
        [...]
        A confirmed case meets the clinical case definition and is epidemiologically linked to another confirmed or probable case or is serologically confirmed. A serologically confirmed case does not need to meet the clinical case definition. It is possible that two epidemiologically linked cases may occur without serologic confirmation and would appropriately be considered confirmed.

        https://www.cdc.gov/mmwr/preview/mmwrhtml/00001225.htm [cdc.gov]

        1990:

        Confirmed: a case that is laboratory confirmed or that meets the clinical case definition and is epidemiologically linked to a confirmed or probable case. A laboratory-confirmed case does not need to meet the clinical case definition... Two probable cases that are epidemiologically linked would be considered confirmed, even in the absence of laboratory confirmation. Only confirmed cases should be reported to the NNDSS.

        https://www.cdc.gov/mmwr/preview/mmwrhtml/00025629.htm [cdc.gov]

        1996:

        Confirmed: a case that is laboratory confirmed or that meets the clinical case definition and is epidemiologically linked to a confirmed case. A laboratory-confirmed case does not need to meet the clinical case definition....Confirmed cases should be reported to NNDSS.

        http://www.cdc.gov/mmwr/preview/mmwrhtml/00047449.htm [cdc.gov]

        So before 1979 there was no definition of "measles", it was just up to the doctor to decide. 1983 - 1990 no blood test confirmation was required. From 1990 - 1996 either a case confirmed by a blood test or two "linked" unconfirmed cases counted. And from 1996 onward only lab confirmed cases or a case linked to a confirmed case is counted.

        Ref. 5: Are you saying that the lack of blinding in a small efficacy study (80% disease in unvaccinated vs 0% in vaccinated) from over 50 years ago proves the vaccine doesn't work?

        The point is the doctors who know a child was vaccinated are less likely to diagnose measles based on the same symptoms. So you can get a drop in diagnoses just by telling doctors that people were vaccinated.

        So to reiterate my point. I want to know how much all these other factors contributed to the drop in cases that were observed. Currently 100% of the drop is being attributed to the vaccine, which we know is wrong.

        From ~500K cases/year to under 1K cases/year (~100 in 2018), whats the relative contribution?

        People stop spreading the disease                 :???
        Doctors reluctant to diagnose vaccinated patients :???
        Tightening/changing diagnostic criteria           :???
        Immunity due to vaccine                           :???

  • (Score: 0) by Anonymous Coward on Friday October 12 2018, @06:57PM (1 child)

    by Anonymous Coward on Friday October 12 2018, @06:57PM (#748005)

    whatever. maybe it's the pesticides. the rate of autism is exploding in such a fashion that it is highly alarming (don't even try to quote big pharma propagandists or their minions in 'government' for the numbers) and until these drug/chemical dealers are held accountable by The People you can't blame some for making their best guesses as to the culprit. these industries are (likely knowingly) making vegetables out of the whole nations' children. 1-2% of the parents are responsible enough to do something about it and the whores of power want to send the pigs in. good luck with that.

    • (Score: 3, Insightful) by Reziac on Saturday October 13 2018, @03:48AM

      by Reziac (2489) on Saturday October 13 2018, @03:48AM (#748168) Homepage

      No, the rate of *diagnosis of autism* is rising, which isn't the same thing. This may be due to more actual autism (possible if we're seeing self-selection for carrier mates), or previously undiagnosed cases now getting diagnosed, or "now that we have a hammer, everything looks like a nail".

      And it's also become highly fashionable among the Silicon Valley set, as a form of victimhood by proxy.

      If it's environmental due to heavy metals or whatever, explain why China, presently drowning in its own pollutants, isn't the world hotbed for autism.

      --
      And there is no Alkibiades to come back and save us from ourselves.