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posted by martyb on Monday November 26 2018, @04:09PM   Printer-friendly
from the slippery-slope-became-a-cliff dept.

Genome-edited baby claim provokes international outcry

A Chinese scientist claims that he has helped make the world's first genome-edited babies — twin girls who were born this month. The announcement has provoked shock, and some outrage, among scientists around the world.

He Jiankui, a genome-editing researcher from the Southern University of Science and Technology of China in Shenzhen, says that he implanted into a woman an embryo that had been edited to disable the genetic pathway that allows a cell to be infected with HIV.

In a video posted to YouTube, He says the girls are healthy and now at home with their parents. Genome sequencing of their DNA has shown that the editing worked, and only altered the gene they targeted, he says.

The scientist's claims have not been verified through independent genome testing or published in a peer-reviewed journal. But, if true, the birth would represent a significant — and controversial — leap in the use of genome-editing. So far these tools have only be used in embryos for research, often to investigate the benefit of using them to eliminate disease-causing mutations from the human germline. But reports of off-target effects in some studies have raised significant safety concerns.

Documents posted on China's clinical trial registry show that He used the ubiquitous CRISPR-Cas9 genome-editing tool to disable a gene called CCR5, which forms a protein that allows HIV to enter a cell. Genome-editing scientist Fyodor Urnov was asked to review documents that described DNA sequence analysis of human embryos and fetuses gene-edited at the CCR5 locus for an article in MIT Technology Review. "The data I reviewed are consistent with the fact that the editing has, in fact, taken place," says Urnov, from the Altius Institute for Biomedical Sciences in Seattle. But he says the only way to tell if the children's genomes have been edited is to independently test their DNA.

Also at STAT News:

The Chinese university where He is an associate professor issued a statement saying that it had been unaware of his research project and that He had been on leave without pay since February, Reuters reported. The work is a "serious violation of academic ethics and standards," Southern University of Science and Technology in Shenzhen said in the statement. The university said it would immediately launch an investigation.

See also: As a genome editing summit opens in Hong Kong, questions abound over China, and why it quietly bowed out


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  • (Score: 2) by sjames on Monday November 26 2018, @09:19PM (1 child)

    by sjames (2882) on Monday November 26 2018, @09:19PM (#766616) Journal

    That was the intention, but CRISPR isn't perfect or exact. It might have worked, or they might have a fascinating novel genetic disease that will manifest in years to come.

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  • (Score: 0) by Anonymous Coward on Monday November 26 2018, @09:37PM

    by Anonymous Coward on Monday November 26 2018, @09:37PM (#766634)

    Or, its just a random mutation to the ccr5 gene.