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posted by martyb on Monday December 31 2018, @02:13PM   Printer-friendly
from the we-have-the-balls-to-print-stories-that-matter! dept.

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism:

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8.

Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.

tl;dr: ibuprofen can reduce testosterone production and interfere with fertility.


Original Submission

 
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  • (Score: 4, Insightful) by RandomFactor on Monday December 31 2018, @02:24PM (19 children)

    by RandomFactor (3682) Subscriber Badge on Monday December 31 2018, @02:24PM (#780257) Journal

    Aspirin, which would never get past the FDA if released today.

    --
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  • (Score: 5, Funny) by The Mighty Buzzard on Monday December 31 2018, @02:29PM (14 children)

    by The Mighty Buzzard (18) Subscriber Badge <themightybuzzard@proton.me> on Monday December 31 2018, @02:29PM (#780259) Homepage Journal

    Yup, they'd probably illegalize willow trees too just to be sure.

    --
    My rights don't end where your fear begins.
    • (Score: 3, Funny) by JoeMerchant on Monday December 31 2018, @02:36PM (12 children)

      by JoeMerchant (3937) on Monday December 31 2018, @02:36PM (#780261)

      That's coming from the NSAID manufacturer's association: "Willow trees are worthless weeds that sap the productive energy from people who see them. They cause obesity, clog your arteries, rot your teeth, and exposure to their sap can cause uncontrolled bleeding." If it weren't so damn expensive to eradicate them all, the NSAID manufacturers' lobbyists would have made a play for them years ago.

      --
      🌻🌻 [google.com]
      • (Score: 1) by khallow on Monday December 31 2018, @03:07PM (6 children)

        by khallow (3766) Subscriber Badge on Monday December 31 2018, @03:07PM (#780268) Journal
        Aspirin is just another NSAID to profit from. It didn't start in the public domain after all.
        • (Score: 4, Insightful) by JoeMerchant on Monday December 31 2018, @03:53PM (5 children)

          by JoeMerchant (3937) on Monday December 31 2018, @03:53PM (#780279)

          Now that Aspirin is public domain, it's time to villify it, like they did saccharine when new alternatives came out, margarine, etc.

          --
          🌻🌻 [google.com]
          • (Score: 1) by khallow on Monday December 31 2018, @06:32PM

            by khallow (3766) Subscriber Badge on Monday December 31 2018, @06:32PM (#780339) Journal
            "Now that Aspirin is public domain". As I already noted, it didn't start in the public domain. RandomFactor's point is that drug regulation has degenerated greatly since Aspirin was first put on the market. This is a separate issue from business marketing strategies.
          • (Score: 3, Interesting) by Runaway1956 on Monday December 31 2018, @09:51PM (2 children)

            by Runaway1956 (2926) Subscriber Badge on Monday December 31 2018, @09:51PM (#780396) Journal

            They haven't spent enough time, money, or effort villifying saccharine. Or margarine. Both are polished turds.

            • (Score: 3, Interesting) by JoeMerchant on Tuesday January 01 2019, @12:42AM (1 child)

              by JoeMerchant (3937) on Tuesday January 01 2019, @12:42AM (#780455)

              Saccharine isn't nearly the polished turd that NutraSweet aka Aspartame is, by comparison saccharine is a well rolled beetle dung ball while Aspartame is a steaming predator patty full of formaldehyde precursors.

              --
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              • (Score: 0) by Anonymous Coward on Wednesday January 02 2019, @02:44AM

                by Anonymous Coward on Wednesday January 02 2019, @02:44AM (#780848)

                Oh come now
                Name something better for killing ants

          • (Score: 2) by dry on Wednesday January 02 2019, @03:55AM

            by dry (223) on Wednesday January 02 2019, @03:55AM (#780875) Journal

            Still trademarked here in Canada and Mexico amongst other countries. Should have demanded that the US re-trademark it as a condition of the CUSMA (NAFTA2) as it was mostly about IP anyways.

      • (Score: 0) by Anonymous Coward on Monday December 31 2018, @07:10PM (4 children)

        by Anonymous Coward on Monday December 31 2018, @07:10PM (#780357)

        I have one of these fuckers in my yard, they are fucking useless. Just grow roots everywhere and wreck cobblestones.

        • (Score: 2) by Phoenix666 on Tuesday January 01 2019, @01:30AM

          by Phoenix666 (552) on Tuesday January 01 2019, @01:30AM (#780476) Journal

          Willow trees are great resources if you know how to use them. Aspirin has been mentioned, but the withies are quite useful for making furniture, baskets, thatching, and that sort of thing. You can make fishing poles and other things, too. If you garden you can use them to create raised beds. They make excellent shade trees to sit under in the summer and have a cool glass of iced tea.

          --
          Washington DC delenda est.
        • (Score: 2, Funny) by Ethanol-fueled on Tuesday January 01 2019, @04:13AM (2 children)

          by Ethanol-fueled (2792) on Tuesday January 01 2019, @04:13AM (#780532) Homepage

          Then fucking stump it and then chain the stump to the back of your Cummins Turbo Diesel and rip it out. Every day you don't, that Willow tree is just laughing at you and thinks you're a pussy. He's telling all his tree friends that you're a pussy, and when your bitch sits under him he tells her the same thing after she rubs his branches off. Open your curtains and look at him. So you see him pointing at you and laughing, and hear his mocking cries in your sleep?

          • (Score: 2, Informative) by Sulla on Tuesday January 01 2019, @04:54AM

            by Sulla (5173) on Tuesday January 01 2019, @04:54AM (#780542) Journal

            >achieving any sort of thing with a dodge

            Thanks for the laugh +1 funny

            --
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          • (Score: 2) by JoeMerchant on Wednesday January 02 2019, @01:11AM

            by JoeMerchant (3937) on Wednesday January 02 2019, @01:11AM (#780811)

            For Brazilian pepper, I cut it down 3 times in 2 years, finally got it by pouring 2 cycle engine fuel into the raw / drilled to a cup stump.

            --
            🌻🌻 [google.com]
    • (Score: 2) by dry on Wednesday January 02 2019, @03:58AM

      by dry (223) on Wednesday January 02 2019, @03:58AM (#780878) Journal

      Then we'd just use Spirea, it's even in the name.

  • (Score: 2) by hendrikboom on Tuesday January 01 2019, @02:23AM (2 children)

    by hendrikboom (1125) Subscriber Badge on Tuesday January 01 2019, @02:23AM (#780491) Homepage Journal

    Aspirin could pass the FDA as a prescription drug -- to combat excessive blood clots.

    For pain, it is a dangerous drug, especially for children. It seems to be a cause for some kind of syndrome hose name I forget.

    As an over-the-counter analgesic -- wouldn't you prefer your blood to remain inside you? It increases the chance of uncontrolled bleeding in a subpopulation. Do you know if you're part of that subpopulation? Have you got enough risk factors yet? Need more?

    -- hendrik

    • (Score: 1) by khallow on Tuesday January 01 2019, @03:20AM

      by khallow (3766) Subscriber Badge on Tuesday January 01 2019, @03:20AM (#780513) Journal
      I know everyone has enough risk factors for death.
    • (Score: 2) by RandomFactor on Tuesday January 01 2019, @07:20AM

      by RandomFactor (3682) Subscriber Badge on Tuesday January 01 2019, @07:20AM (#780569) Journal

      Here's some reading: http://www.cnn.com/2010/HEALTH/12/22/aspirin.history/index.html [cnn.com]

      Aspirin's been around and a medical staple since the late 1800's. It's not perfect, but if used properly it generally lives up to it's designation as a wonder drug.

      (CNN) -- If you take aspirin, you've got a pain reliever, heart attack preventer and possible cancer preventer rolled into one tablet.

      and that's ignoring using it as a blood thinner/anti-coagulant which seems to be a forgotten capability.

      "If I'm stranded on a desert island, and I can take one drug with me, that's the one I'm taking," Watson said.

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      В «Правде» нет известий, в «Известиях» нет правды
  • (Score: 1, Interesting) by Anonymous Coward on Tuesday January 01 2019, @04:43AM

    by Anonymous Coward on Tuesday January 01 2019, @04:43AM (#780540)

    Someone didn't read the article. Shocking, I know.
    They tested ibuprofen but aspirin and Tylenol are thought to work similarly. I wouldn't bet on aspirin being a safe alternative for the anti-testosterone problem.