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from the we-have-the-balls-to-print-stories-that-matter! dept.
Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism:
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8.
Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.
tl;dr: ibuprofen can reduce testosterone production and interfere with fertility.
(Score: 1, Interesting) by Anonymous Coward on Monday December 31 2018, @03:06PM (14 children)
Always figured there was some merit in just shrugging off pain, in addition to the macho "cred" that comes from peers when gutting-out childhood injuries. So, I've used painkillers very infrequently.
On the other hand, not getting proper treatment after an injury was a false economy. As a kid, crashing a dirt bike (motorcycle) numerous times I would have done well to visit a physical therapist or other "body work" expert...at the time. Might have reduced the level of back pain that I have now.
(Score: 3, Interesting) by RS3 on Monday December 31 2018, @03:44PM (4 children)
Possibly. Inflammation reduction usually lessens localized tissue damage, so in the short-term NSAIDs can be good.
Another downside of pain killers in general is they can mask a problem, delaying corrective treatment.
Also, they could embolden risk-takers. Of course alcohol does that very well.
(Score: -1, Troll) by Anonymous Coward on Monday December 31 2018, @04:20PM (1 child)
"Also, they could embolden risk-takers."
-
What's the matter, faggot ?
You don't like people who have more courage than you do ?
Hang yourself.
(Score: 3, Funny) by fritsd on Monday December 31 2018, @05:01PM
Happy new year to you too! May you be as bold and intrepid as May! :-/
https://www.caglecartoons.com/viewimage.asp?ID={3EBF4BA2-6B8F-4AB4-981E-8A7B8E9C5892} [caglecartoons.com]
(cartoon by Jos Collignon, originally in de Volkskrant)
One of Theresa May's ministers said: "we've had enough of experts", and many of them have tried to explain that actual brexit risk evaluations were top secret, or lost somewhere in the basement behind the door that says "beware of the leopard".
So it's probably best to press on with it, to see what will happen to the UK in 3 months.
(Score: 2) by DannyB on Monday December 31 2018, @04:57PM
grandparent: > shrug off pain
I agree.
parent: > in the short-term NSAIDs can be good.
Yep. Long term severe arthritis problems can be helped by long term use of NSAIDs. But that comes with problems too. There are lots of prescription NSAIDs. Your doctor can work with you to find a potent one that you can take several times per day without side effects . . . for you! Every drug has side effects for someone. Only the very safest ones ever get to be over the counter.
> downside of pain killers in general
Even with potent NSAIDs, you can still be in pain. Just about anyone with arthritis will tell you there are good days and bad days. When the pain gets to be too much, there are good prescription opiate drugs. But if those are for anything other than occasional use, the end of that story will not be a good one.
That brings me back to: shrug off the pain, and NSAIDs are helpful, and long term use may, in some cases, be more beneficial, on balance, than the long term detriment of taking those NSAIDs. But that is something done under a doctor's supervision, for decades or more.
The lower I set my standards the more accomplishments I have.
(Score: 2) by RandomFactor on Monday December 31 2018, @05:55PM
There was evidence out some decades back that they reduced muscle growth associated with exercise some also.
В «Правде» нет известий, в «Известиях» нет правды
(Score: 2) by The Mighty Buzzard on Monday December 31 2018, @05:14PM (2 children)
Painkillers are fine for situations like when you have a pulled muscle and the pain is causing it to cramp and heal slower. Other than that, you should use as little of them as you can manage. None of them at effective pain killing doses are especially good for you.
My rights don't end where your fear begins.
(Score: 2, Informative) by Anonymous Coward on Monday December 31 2018, @06:48PM (1 child)
A major benefit of NSAID is relieving inflammation, an immune response that actually hinders healing of muscle/bone tissue injury.
(Score: 3, Interesting) by The Mighty Buzzard on Tuesday January 01 2019, @04:01AM
You reckon a little time off healing those is worth a bleeding ulcer? I've tried both. I prefer a little extra recovery time.
My rights don't end where your fear begins.
(Score: 1, Funny) by Anonymous Coward on Monday December 31 2018, @06:45PM (4 children)
How about wearing proper safety gear, not taking undue risks and not riding faster than you can think?
(Score: 0) by Anonymous Coward on Monday December 31 2018, @09:54PM (2 children)
Can't you read?
Opening line of parent is, "As a kid..."
(Score: 0) by Anonymous Coward on Tuesday January 01 2019, @01:05AM (1 child)
When you were a kid and riding motorcycles - you couldn't think?
(Score: 1) by khallow on Tuesday January 01 2019, @03:22AM
(Score: 2) by The Mighty Buzzard on Tuesday January 01 2019, @03:57AM
That pretty much negates everything that makes riding a dirtbike fun. Pansy.
My rights don't end where your fear begins.
(Score: 0) by Anonymous Coward on Tuesday January 01 2019, @08:07AM
I think I have a better pain threshold than most males (ones I've befriended anyway) albeit I'm a fucking baby with man cold. I'm virile with hair in everywhere but on my palms and the bottoms of my feet!