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from the we-have-the-balls-to-print-stories-that-matter! dept.
Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism:
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8.
Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.
tl;dr: ibuprofen can reduce testosterone production and interfere with fertility.
(Score: 2) by DannyB on Monday December 31 2018, @04:57PM
grandparent: > shrug off pain
I agree.
parent: > in the short-term NSAIDs can be good.
Yep. Long term severe arthritis problems can be helped by long term use of NSAIDs. But that comes with problems too. There are lots of prescription NSAIDs. Your doctor can work with you to find a potent one that you can take several times per day without side effects . . . for you! Every drug has side effects for someone. Only the very safest ones ever get to be over the counter.
> downside of pain killers in general
Even with potent NSAIDs, you can still be in pain. Just about anyone with arthritis will tell you there are good days and bad days. When the pain gets to be too much, there are good prescription opiate drugs. But if those are for anything other than occasional use, the end of that story will not be a good one.
That brings me back to: shrug off the pain, and NSAIDs are helpful, and long term use may, in some cases, be more beneficial, on balance, than the long term detriment of taking those NSAIDs. But that is something done under a doctor's supervision, for decades or more.
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