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Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism:
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8.
Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.
tl;dr: ibuprofen can reduce testosterone production and interfere with fertility.
(Score: 2) by The Mighty Buzzard on Monday December 31 2018, @05:14PM (2 children)
Painkillers are fine for situations like when you have a pulled muscle and the pain is causing it to cramp and heal slower. Other than that, you should use as little of them as you can manage. None of them at effective pain killing doses are especially good for you.
My rights don't end where your fear begins.
(Score: 2, Informative) by Anonymous Coward on Monday December 31 2018, @06:48PM (1 child)
A major benefit of NSAID is relieving inflammation, an immune response that actually hinders healing of muscle/bone tissue injury.
(Score: 3, Interesting) by The Mighty Buzzard on Tuesday January 01 2019, @04:01AM
You reckon a little time off healing those is worth a bleeding ulcer? I've tried both. I prefer a little extra recovery time.
My rights don't end where your fear begins.