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from the we-have-the-balls-to-print-stories-that-matter! dept.
Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism:
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8.
Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.
tl;dr: ibuprofen can reduce testosterone production and interfere with fertility.
(Score: 2) by PiMuNu on Monday December 31 2018, @06:49PM (3 children)
Since when are the Netherlands not in Northern Europe?
(Score: 1) by fritsd on Monday December 31 2018, @07:02PM
More like West Europe, innit?
(Score: 0) by Anonymous Coward on Monday December 31 2018, @09:33PM (1 child)
"Northern Europe" usually means the Nordic plus Baltic states. From the truth [wikipedia.org]:
From that description, The Netherlands would also be considered central-western, thus part of neither Northern nor Southern Europe.
I also stumbled upon the term Baltoscandia [wikipedia.org]. Fun stuff.
(Score: 2) by PiMuNu on Tuesday January 01 2019, @09:44AM
Ah, I am used to this definition:
"Historically, when Europe was dominated by the Roman Empire, everything not near the Mediterranean region was termed Northern Europe, including southern Germany, all of the Low Countries, and Austria. This meaning is still used today in some contexts, for example, discussions of the Northern Renaissance. "
My bad.