Stories
Slash Boxes
Comments

SoylentNews is people

posted by martyb on Monday December 31 2018, @02:13PM   Printer-friendly
from the we-have-the-balls-to-print-stories-that-matter! dept.

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism:

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8.

Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.

tl;dr: ibuprofen can reduce testosterone production and interfere with fertility.


Original Submission

 
This discussion has been archived. No new comments can be posted.
Display Options Threshold/Breakthrough Mark All as Read Mark All as Unread
The Fine Print: The following comments are owned by whoever posted them. We are not responsible for them in any way.
  • (Score: 3, Interesting) by Runaway1956 on Monday December 31 2018, @09:51PM (2 children)

    by Runaway1956 (2926) Subscriber Badge on Monday December 31 2018, @09:51PM (#780396) Journal

    They haven't spent enough time, money, or effort villifying saccharine. Or margarine. Both are polished turds.

    Starting Score:    1  point
    Moderation   +1  
       Interesting=1, Total=1
    Extra 'Interesting' Modifier   0  
    Karma-Bonus Modifier   +1  

    Total Score:   3  
  • (Score: 3, Interesting) by JoeMerchant on Tuesday January 01 2019, @12:42AM (1 child)

    by JoeMerchant (3937) on Tuesday January 01 2019, @12:42AM (#780455)

    Saccharine isn't nearly the polished turd that NutraSweet aka Aspartame is, by comparison saccharine is a well rolled beetle dung ball while Aspartame is a steaming predator patty full of formaldehyde precursors.

    --
    🌻🌻 [google.com]
    • (Score: 0) by Anonymous Coward on Wednesday January 02 2019, @02:44AM

      by Anonymous Coward on Wednesday January 02 2019, @02:44AM (#780848)

      Oh come now
      Name something better for killing ants