Submitted via IRC for takyon
Engineers create an inhalable form of messenger RNA
Messenger RNA, which can induce cells to produce therapeutic proteins, holds great promise for treating a variety of diseases. The biggest obstacle to this approach so far has been finding safe and efficient ways to deliver mRNA molecules to the target cells.
In an advance that could lead to new treatments for lung disease, MIT researchers have now designed an inhalable form of mRNA. This aerosol could be administered directly to the lungs to help treat diseases such as cystic fibrosis, the researchers say.
[...] The researchers showed that they could induce lung cells in mice to produce a target protein — in this case, a bioluminescent protein. If the same success rate can be achieved with therapeutic proteins, that could be high enough to treat many lung diseases, the researchers say.
[...] The particles the team created consist of spheres, approximately 150 nanometers in diameter, with a tangled mixture of the polymer and mRNA molecules that encode luciferase, a bioluminescent protein. The researchers suspended these particles in droplets and delivered them to mice as an inhalable mist, using a nebulizer.
[...] The researchers found that 24 hours after the mice inhaled the mRNA, lung cells were producing the bioluminescent protein. The amount of protein gradually fell over time as the mRNA was cleared. The researchers were able to maintain steady levels of the protein by giving the mice repeated doses, which may be necessary if adapted to treat chronic lung disease.
(Score: 2) by Runaway1956 on Thursday January 10 2019, @03:28PM (3 children)
Yeah, man, but how does it compare to Testors model airplane glue?
(Score: 2) by JoeMerchant on Thursday January 10 2019, @04:11PM (1 child)
Party Eyes! Luciferase encoding mRNA eyedrops, make your eyes glow green for the weekend.
🌻🌻 [google.com]
(Score: 0) by Anonymous Coward on Thursday January 10 2019, @04:19PM
Not even interesting, man. My mom gave me green eyes, and my girl gave me a green penis.
(Score: 0) by Anonymous Coward on Thursday January 10 2019, @06:15PM
Real Men(tm) use aircraft dope.