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The anti-cancer drug dasatnib in combination with quercetin being trialed for safety against lung fibrosis has shown impressive anti-aging results.
Participants in the trial were ~70 years old and suffering from pulmonary fibrosis a debilitating and eventually fatal disease. After the trial, 100% of the study showed improvement
participants were able to walk faster, get up from a chair more quickly and scored better in ability tests.
The benefit is a result of removing 'zombie cells' from the body.
Senescent cells - also known as zombie cells - are not completely dead so are not cleared out by the body, but are too damaged to repair tissue or carry out normal functions. Unable to repair itself or clear out the waste, the body gradually deteriorates.
Previously animal studies have shown that removing these cells reverses the ageing process, extends lifespan, and restores lost youth.
Better yet, it does not sound like a pill every day for the rest of your life sort of thing
“It has a hit-and-run effect,” added Dr Kirkland. “The drug starts working quickly and we would ideally like to be able to give it just once a month.”
Of course increasing the cost 30x should nicely take care of that drawback.
(Score: 3, Informative) by Pax on Thursday January 10 2019, @11:25PM (6 children)
I have idiopathic pulmonary fibrosis. i was diagnosed 4 months ago. So as far as i am concerned this shit can't get to market fast enough.
Who'd have thought acid reflux could lead to this shit? as was the case with me
(Score: 3, Interesting) by RS3 on Friday January 11 2019, @04:29AM (5 children)
I'm no doctor (wish I was) but are you saying acid reflux caused idiopathic pulmonary fibrosis?
Could it be parallel diseases caused by something else?
Please look for drug trials- I'm sure you'll get into one.
(Score: 2) by Pax on Wednesday January 16 2019, @10:20PM (4 children)
yeah man. it's a known connection. i get insane reflux even though I get tablets(ranitidine) and also kolanticon gel for when the reflux hits.
At night though I can wake up choking on the reflux. sometimes a portion of it gets inhaled and scars the lungs.
I live in Scotland but have mentioned this to my GP and he's checking out for any trials running locally.
For now though it's pulmonary rehabilitation and 200/6 fostair 2 x puffs twice a day plus 100 micrograms salamol (Ventolin) inhaler when needed.
(Score: 2) by RS3 on Wednesday January 16 2019, @10:59PM (2 children)
I'm in USA and doctors have to prescribe most drugs- we can't just buy them and try, although I've been to a country where you could buy almost anything without a prescription (not narcotics). I don't know about Scotland, but if you can need a doctor to prescribe these, you should be able to get both dasatnib and quercetin in Scotland. If not, try to buy abroad. Both are oral pills.
(Score: 2) by Pax on Friday January 18 2019, @07:48AM (1 child)
prescriptions are totally free in Scotland except for those earning over 50,000 GBP as i recall.
I will ask my doctor about those two meds.. I am fairly sure though that they might not be on the list of approved medicines...
Just googled dastanib, seems it's used for untreated chronic myeloid leukaemia but does show good results for IPF so that should be fine to get a prescription.
Quercetin though I don't think it'd be available on prescription but I can ask and see what he says.
cheers for the info RS3.. it's appreciated
(Score: 2) by RS3 on Friday January 18 2019, @06:31PM
Oh, you're very welcome, but I'm mostly just parroting the article / synopsis. That said, I do wish I had gone to medical school.
Dastanib is quite expensive, so I'm not sure if that becomes a factor when asking for an "off-label" medication, but that's the magic phrase you might want to use when talking to a doctor who might not know anything about it. Please refer them to the research studies.
In the US, one of our absolute top medical centers is Mayo Clinic, so here are a few other ideas (medications "pirfenidone (Esbriet) and nintedanib (Ofev)" listed later in the page): https://www.mayoclinic.org/diseases-conditions/pulmonary-fibrosis/diagnosis-treatment/drc-20353695 [mayoclinic.org]
(Score: 2) by RS3 on Friday January 18 2019, @06:48PM
Again, just to reiterate, I see that many of the underlying mechanisms of PF cause both of the symptoms you have- lung issues and GI problems, and (and many more worth looking into) so I'm not sure that the GERD caused the PF.
Years and years before it became somewhat commonspeak I was pointing out that "correlation is not causation". Just saying it might not be, and that there are many other problems the underlying disease can cause, and is often linked to sarcoidosis and many other connective tissue diseases. Which reminds me that a big study of connective tissue diseases and problems just came out recently, and much of it is thought to be autoimmune. Which I feel is the cause of many diseases and syndromes, possibly triggered by all of the crazy chemicals and compounds we humans have created and subject ourselves to, but this could go on and on so I'll stop here. :)