SoylentNews is people
SoylentNews
The anti-cancer drug dasatnib in combination with quercetin being trialed for safety against lung fibrosis has shown impressive anti-aging results.
Participants in the trial were ~70 years old and suffering from pulmonary fibrosis a debilitating and eventually fatal disease. After the trial, 100% of the study showed improvement
participants were able to walk faster, get up from a chair more quickly and scored better in ability tests.
The benefit is a result of removing 'zombie cells' from the body.
Senescent cells - also known as zombie cells - are not completely dead so are not cleared out by the body, but are too damaged to repair tissue or carry out normal functions. Unable to repair itself or clear out the waste, the body gradually deteriorates.
Previously animal studies have shown that removing these cells reverses the ageing process, extends lifespan, and restores lost youth.
Better yet, it does not sound like a pill every day for the rest of your life sort of thing
“It has a hit-and-run effect,” added Dr Kirkland. “The drug starts working quickly and we would ideally like to be able to give it just once a month.”
Of course increasing the cost 30x should nicely take care of that drawback.
(Score: 4, Interesting) by DrkShadow on Friday January 11 2019, @01:01AM (3 children)
I have something similar, except I only get three days. Ever since I was evelen years old, take Claritin, allergies have cleared up. Cool! Three days later, they're back. Fourth day, it's like I'm not taking anything. Switch to Allegra. Same thing, three days, and they're back. The green one, same thing. It's apparently a known thing that antihistamines are only meant for acute use, and they typically lose efficacy after a couple weeks -- as is the case with you. (My immune system is so overly strong I'm plagued with auto-immune diseases.)
Instead of constant antihistamine use, you should be going with the nose sprays that are out. Budesonide nose spray (lime green one, generic name) really works exceptionally well for me. I also tried Nasonex, but that did next to nothing from what I can recall.
the nasal sprays tend to work by gene modification -- they alter the cells in the affected area to not produce histamines, and so you never have the effects of allergic reaction. After I started taking this, I was disgusted when I went out in my back yard and was pounded with the heavy, wet, flowery, warm air of the garden. Ugh. (That was perhaps the first time I'd ever smelled something like that.) Its efficacy seems great -- it's not really doing much more than preventing over-production of histamines by the body. Allergies are an outlier, so they're not particularly needed, and I don't get injured in the face enough that I'm concerned about lacking the ability to become inflamed there. Do the nose spray once a day, even if you don't "need" it. It takes about 3 days to become effective, and in the first few days you might do two doses a day.
The nasal spray helps with scratchy eyes and throat slightly as some of the material leeches to those areas, but it's not necessarily guaranteed. I'm not sure it's good to squirt them in your eyes, but on the worst days, a Loratadine dose will clear things up. It's pretty infrequent that I've had to do both.
One other thing that worked for me, I was really, really trying to get something before I knew that the nose sprays worked well. First, doubling up. The drug facts sheet says people took six times the recommended dosage without ill effect, so doubling up on bad days isn't so much a problem -- except, still, diminishing returns. Second, alternating drugs. There are three popular modern antihistamines -- Loratadine, Cetirizine, and Fexofenadine. My goal was to avoid accumulating a tolerance by rotating which drugs I take. I also wanted to alternate them by skipping which drug is filtered by which organ -- Fexofenadine by the liver, and the other two by the kidneys. So, one day fexofenadine, certizirine, fexofenadine, loratadine, fexofenadine, repeat.
Alternating in this way definitely prevented my body from building up a "tolerance" to the antihistamine. The real drawback is that the effects wear off after 24 hours. The fix here, again, is the nose spray: it takes 3 days to get running, and it takes three days to a week to fully wear off. By that time, the strong allergy days have hopefully left.
Interesting..
(Score: 0) by Anonymous Coward on Friday January 11 2019, @01:15AM
I used to use those spray but for me quercetin works better (the spray doesn't do much for my eyes) with the drawback of requiring 3 pills a day instead of 1 mist
(Score: 1) by optotronic on Friday January 11 2019, @02:42AM
I just discovered alternating antihistamines within the past year or so. I didn't know anyone else was doing it. It certainly helps me.
(Score: 2) by Spamalope on Friday January 11 2019, @02:53AM
First, forgive me if you already know about this stuff, you may...
Have you tried ketotifen? It works partly by being a mast cell stabilizer, so the release of histamines is slowed and you don't need as high an anti-histamine dose.
If it does work well, you should have your tryptase levels checked to screen for mast cell disease (actually - you should already have been tested with your history - but do make sure)