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posted by Fnord666 on Friday February 22 2019, @09:13PM   Printer-friendly
from the I-remember-now dept.

Submitted via IRC for Bytram

New molecules reverse memory loss linked to depression, aging

New therapeutic molecules developed at Toronto's Centre for Addiction and Mental Health (CAMH) show promise in reversing the memory loss linked to depression and aging.

These molecules not only rapidly improve symptoms, but remarkably, also appear to renew the underlying brain impairments causing memory loss in preclinical models. These findings were presented today at the American Association for the Advancement of Science (AAAS) Annual Meeting in Washington DC.

"Currently there are no medications to treat cognitive symptoms such as memory loss that occur in depression, other mental illnesses and aging," says Dr. Etienne Sibille, Deputy Director of the Campbell Family Mental Health Research Institute at CAMH and lead scientist on the study.

What's unique and promising about these findings, in the face of many failures in drug development for mental illness, is that the compounds are highly targeted to activate the impaired brain receptors that are causing memory loss, he says.

It took a series of studies – the most recent appearing in January 2019 in Molecular Neuropsychiatry – to reach this stage. First, Dr. Sibille and his team identified the specific impairments to brain cell receptors in the GABA neurotransmitter system. Then they showed that these impairments likely caused mood and memory symptoms in depression and in aging.


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  • (Score: 0) by Anonymous Coward on Saturday February 23 2019, @03:59PM

    by Anonymous Coward on Saturday February 23 2019, @03:59PM (#805601)

    look up gamma hydroxy butyrate (or GHB or some of its analogues).

    you will find that it had a lot of medical capability; a problem is the lack of patenting a naturally occuring molecule with theraputic potential.

    and so after vilification and its subsquent removal as an over-the-counter supplement, the search has been on to find something that is patentable and similarly affects the GABA system.