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Sleep Tight! Researchers Identify the Beneficial Role of Sleep:
Why do animals sleep? Why do humans "waste" a third time of their lives sleeping? Throughout evolution sleep has remained universal and essential to all organisms with a nervous system, including invertebrates such as flies, worms, and even jellyfish. But the reason why animals sleep -- despite the continuous threat of predators -- still remains a mystery, and is considered among the biggest unanswered questions in life sciences.
In a new study, published today in the journal Nature Communications, researchers at Bar-Ilan University in Israel reveal a novel and unexpected function of sleep that they believe could explain how sleep and sleep disturbances affect brain performance, aging and various brain disorders.
Using 3D time-lapse imaging techniques in live zebrafish, the researchers were able to define sleep in a single chromosome resolution and show, for the first time, that single neurons require sleep in order to perform nuclear maintenance.
DNA damage can be caused by many processes including radiation, oxidative stress, and even neuronal activity. DNA repair systems within each cell correct this damage. The current work shows that during wakefulness, when chromosome dynamics are low, DNA damage consistently accumulates and can reach unsafe levels.
The role of sleep is to increase chromosome dynamics, and normalize the levels of DNA damage in each single neuron. Apparently, this DNA maintenance process is not efficient enough during the online wakefulness period and requires an offline sleep period with reduced input to the brain in order to occur. "It's like potholes in the road," says Prof. Lior Appelbaum, of Bar-Ilan University's Mina and Everard Goodman Faculty of Life Sciences and Gonda (Goldschmied) Multidisciplinary Brain Research Center, who led the study. "Roads accumulate wear and tear, especially during daytime rush hours, and it is most convenient and efficient to fix them at night, when there is light traffic."
Journal Reference:
D. Zada, I. Bronshtein, T. Lerer-Goldshtein, Y. Garini, L. Appelbaum. Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-08806-w
I think now would be a good time to take a nap.
(Score: 2) by MichaelDavidCrawford on Thursday March 14 2019, @05:06PM
Kuro5hin's mumble prepared histograms of each Kuron's post timestamps, thereby quite-clearly deducing the time zones from which all but one of us posted.
Which one?
"When does he sleep?" mumble asked of my own perfectly-flat histogram.
I really do sleep far far more than anyone I have ever so much as heard of, it's just that my Circadian Rhythm is so profoundly dysfunctional that I range from days without sleeping, days of sleep interrupted by naught but potty-breaks, cat naps, passing out from sheer exhaustion as well as - I have only recently understood the cause of - frequent but quite-brief Syncope, or fainting.
I at first regarded my Syncope as an extreme form of the Brain Seizures that started occurring not long before the Syncope did - the seizures in Late May of 2010, the Syncope in I think the Spring of 2013, but I don't clearly recall. That the Doctors were at a loss to explain them lead to my calling them "Drop-Outs". I don't actually fall over nor pass out, rather for quite a lot less then a second my entire body relaxes, leading my head to drop forward, with my own internal experience being quite powerfully Hallucinogenic.
You Have Absolutely No Idea.
To Wit:
_This_ is going to be my very first Medium Essay, despite my sheer hatred of Medium's requirement that I log in either with Twitter or Facebook. Despite that, the ensuing $$$$$ Pussy! will be _well_ worth the effort, surely you must agree?
Yes I Have No Bananas. [gofundme.com]