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posted by chromas on Monday April 01 2019, @10:57PM   Printer-friendly
from the I-got-colorectal-cancer-from-YouTube-comments dept.

Submitted via IRC for Bytram

High-fructose corn syrup boosts intestinal tumor growth in mice

First, Yun and her colleagues generated a mouse model of early-stage colon cancer where APC gene is deleted. "APC is a gatekeeper in colorectal cancer. Deleting this protein is like removing the breaks of a car. Without it, normal intestinal cells neither stop growing nor die, forming early stage tumors called polyps. More than 90 percent of colorectal cancer patients have this type of APC mutation," Yun said.

Using this mouse model of the disease, the team tested the effect of consuming sugar-sweetened water on tumor development. The sweetened water was 25 percent high-fructose corn syrup, which is the main sweetener of sugary drinks people consume. High-fructose corn syrup consists of glucose and fructose at a 45:55 ratio.

When the researchers provided the sugary drink in the water bottle for the APC-model mice to drink at their will, mice rapidly gained weight in a month. To prevent the mice from being obese and mimic humans' daily consumption of one can of soda, the researchers gave the mice a moderate amount of sugary water orally with a special syringe once a day. After two months, the APC-model mice receiving sugary water did not become obese, but developed tumors that were larger and of higher-grade than those in model mice treated with regular water.

[...] The team then investigated the mechanism by which this sugar promoted tumor growth. They discovered that the APC-model mice receiving modest high-fructose corn syrup had high amounts of fructose in their colons. "We observed that sugary drinks increased the levels of fructose and glucose in the colon and blood, respectively and that tumors could efficiently take up both fructose and glucose via different routes."

Using cutting-edge technologies to trace the fate of glucose and fructose in tumor tissues, the team showed that fructose was first chemically changed and this process then enabled it to efficiently promote the production of fatty acids, which ultimately contribute to tumor growth.

[...] To determine whether fructose metabolism or increased fatty acid production was responsible for sugar-induced tumor growth, the researchers modified APC-model mice to lack genes coding for enzymes involved in either fructose metabolism or fatty acid synthesis. One group of APC-model mice lacked an enzyme KHK, which is involved in fructose metabolism, and another group lacked enzyme FASN, which participates in fatty acid synthesis. They found that mice lacking either of these genes did not develop larger tumors, unlike APC-model mice, when fed the same modest amounts of high-fructose corn syrup.


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  • (Score: 4, Informative) by AthanasiusKircher on Monday April 01 2019, @11:28PM (3 children)

    by AthanasiusKircher (5291) on Monday April 01 2019, @11:28PM (#823315) Journal

    Indeed. I was about to write something similar. Sucrose is just a bonded fructose and glucose molecule that mostly disassociates by the time it reaches the intestines, leaving a 50:50 glucose-fructose solution, very similar to HFCS. Natural honey also has a similar glucose-fructose mixture to HFCS (though with some other sugars and trace stuff mixed in in relatively small quantities). And note that other stuff "natural foods" folks tend to use as substitutes -- like agave nectar -- often tend to have an even higher (worse?) ratio of fructose to glucose.

    I'm by no means a defender of HFCS, which seems to show up way too much in all sorts of foods where it's unnecessary. But this study likely got a bigger grant and more media attention by being able to run a headline complaining about a substance people are anxious about now. I hope they do similar studies with sucrose and honey and other things to see if there's any significant difference in effect.

    TL;DR: Mexican Coke (or your agave-nectar infused drink) is likely not a health food, and I doubt drinking loads of it is better than drinking loads of HFCS-filled Coke.

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  • (Score: 3, Interesting) by JoeMerchant on Tuesday April 02 2019, @01:50AM (2 children)

    by JoeMerchant (3937) on Tuesday April 02 2019, @01:50AM (#823365)

    My mother has been preaching the "sugar is sugar" thing ever since she took bio-chem in the 1960s. While she's not wrong, the agricultural residues from Agave and Maple farms are quite different from those found in sugar cane fields and corn farms. Of all those, I would think that corn has the most exposure to pesticides, herbicides, and all those other "perfectly harmless" productivity enhancing chemicals brought to us by our friends at Monstranto.

    --
    🌻🌻 [google.com]
    • (Score: 0) by Anonymous Coward on Tuesday April 02 2019, @10:14PM

      by Anonymous Coward on Tuesday April 02 2019, @10:14PM (#823821)

      Indeed. Honey in particular brings a lot "with it"

      For a single-signal sample, eg. "tests by Abraxis found glyphosate residues in 41 of 69 honey samples" https://www.reuters.com/article/us-food-agriculture-glyphosate-idUSKBN0N029H20150410 [reuters.com]

    • (Score: 0) by Anonymous Coward on Tuesday April 02 2019, @10:46PM

      by Anonymous Coward on Tuesday April 02 2019, @10:46PM (#823839)

      yeah, it's not the "high fructose" part we don't understand it's the "corn syrup" part some people don't seem to understand. the whole point of the gmo corn this slurry is made from is that it can live while being drenched with pesticide, ffs.