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Submitted via IRC for Bytram
High-fructose corn syrup boosts intestinal tumor growth in mice
First, Yun and her colleagues generated a mouse model of early-stage colon cancer where APC gene is deleted. "APC is a gatekeeper in colorectal cancer. Deleting this protein is like removing the breaks of a car. Without it, normal intestinal cells neither stop growing nor die, forming early stage tumors called polyps. More than 90 percent of colorectal cancer patients have this type of APC mutation," Yun said.
Using this mouse model of the disease, the team tested the effect of consuming sugar-sweetened water on tumor development. The sweetened water was 25 percent high-fructose corn syrup, which is the main sweetener of sugary drinks people consume. High-fructose corn syrup consists of glucose and fructose at a 45:55 ratio.
When the researchers provided the sugary drink in the water bottle for the APC-model mice to drink at their will, mice rapidly gained weight in a month. To prevent the mice from being obese and mimic humans' daily consumption of one can of soda, the researchers gave the mice a moderate amount of sugary water orally with a special syringe once a day. After two months, the APC-model mice receiving sugary water did not become obese, but developed tumors that were larger and of higher-grade than those in model mice treated with regular water.
[...] The team then investigated the mechanism by which this sugar promoted tumor growth. They discovered that the APC-model mice receiving modest high-fructose corn syrup had high amounts of fructose in their colons. "We observed that sugary drinks increased the levels of fructose and glucose in the colon and blood, respectively and that tumors could efficiently take up both fructose and glucose via different routes."
Using cutting-edge technologies to trace the fate of glucose and fructose in tumor tissues, the team showed that fructose was first chemically changed and this process then enabled it to efficiently promote the production of fatty acids, which ultimately contribute to tumor growth.
[...] To determine whether fructose metabolism or increased fatty acid production was responsible for sugar-induced tumor growth, the researchers modified APC-model mice to lack genes coding for enzymes involved in either fructose metabolism or fatty acid synthesis. One group of APC-model mice lacked an enzyme KHK, which is involved in fructose metabolism, and another group lacked enzyme FASN, which participates in fatty acid synthesis. They found that mice lacking either of these genes did not develop larger tumors, unlike APC-model mice, when fed the same modest amounts of high-fructose corn syrup.
(Score: 2) by JoeMerchant on Tuesday April 02 2019, @01:47AM (4 children)
Is the problem with sugar, or just with excessive caloric intake? Butter is even more calorie dense, if the mice would eat an equivalent serving of butter it would make a good test of whether sugar is the demon, or fat.
Just to be sure, you can eat butter-cream icing.
🌻🌻 [google.com]
(Score: 1) by DECbot on Tuesday April 02 2019, @04:26AM (2 children)
A high sugar diet is a high fat diet. Fructose and excess glucose enters the liver and gets processed into fat cells. There's a lot additional damage the sugar (specifically fructose and ethanol) does to the liver, cardiovascular, and metabolic systems because it (sugar) is a cronic toxin. And what's the best detox for this? Naturally occurring fiber consumed with the sugar. That's why an apple is healthy and apple juice is not. Juicing the apple separates the sugars from the fiber.
A high calories diet is the demon. Luckily for us in the western world, it comes in many different flavors to choose from.
cats~$ sudo chown -R us /home/base
(Score: 3, Interesting) by FatPhil on Tuesday April 02 2019, @07:02AM
Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
(Score: 2) by JoeMerchant on Tuesday April 02 2019, @05:06PM
If we all lived forever, overpopulation would be an even bigger problem.
🌻🌻 [google.com]
(Score: 2) by FatPhil on Tuesday April 02 2019, @06:49AM
You could have just watched the vid I pointed you towards, all the answers are there.
Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves