Submitted via IRC for Bytram
The findings, published this week in Nature Communications, suggest that, although heavy drinking is a prerequisite for AUD, variants in several genes -- DRD2 and SIX3, for example -- may need to be present for people to develop AUD.
"This study has revealed an important genetic independence of these two traits that we haven't seen as clearly before," said Henry R. Kranzler, MD, a professor of Psychiatry in the Perelman School of Medicine at the University of Pennsylvania, and first author of the study. "Focusing on variants only linked to AUD may help identify people at risk and find targets for the development of medications to treat it. The same applies to alcohol consumption, as those variants could inform interventions to help reduce consumption in heavy drinkers, who face their own set of adverse effects."
[...] Environmental, hereditary, and genetic factors all play a role in AUD; however, many of the variants across the genome believed to be associated with the disorder remain to be identified.
For the study, the researchers used genetic data from the multi-ethnic Million Veteran Program (MVP), a national, voluntary research program sponsored by the Department of Veterans Affairs, which includes white, African-American, Latino, and Asian participants. The diverse study sample is notable, in that it included more than 50,000 African-Americans, one of the largest genome-wide studies of this population. Scores from the Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) screenings and AUD diagnoses were obtained from the same population (a total of 274,424 people) to conduct the GWAS for the two traits. The researchers also analyzed other data from health records to look for correlations between genes and diseases, as well as other non-alcohol related traits.
(Score: 2) by DannyB on Thursday April 04 2019, @10:02PM (2 children)
All humans have the right to a government mandated DNA test. And to hope that they get a passing grade. According to government mandated minimum standards.
The lower I set my standards the more accomplishments I have.
(Score: 2) by mhajicek on Friday April 05 2019, @02:08AM (1 child)
Sorry, your insurance will cost ten times as much due to your predispositions.
The spacelike surfaces of time foliations can have a cusp at the surface of discontinuity. - P. Hajicek
(Score: 2) by DannyB on Friday April 05 2019, @02:58PM
Maybe you missed the part about hoping you get a passing grade on your government mandated DNA test.
The lower I set my standards the more accomplishments I have.